2013 Fiscal Year Final Research Report

Challenge of extending warm ischemic time in rat liver transplantation from cardiac death donors

Research Project

Project/Area Number	22591405
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	General surgery
Research Institution	Nagoya University (2011-2013) Kyoto University (2010)
Principal Investigator	OGURA Yasuhiro 名古屋大学, 医学部附属病院, 病院准教授 (20335251)
Co-Investigator(Kenkyū-buntansha)	UEMOTO Shinji 京都大学, 医学系研究科(研究院), 教授 (40252449)
Project Period (FY)	2010-04-01 – 2013-03-31
Keywords	心停止ドナー / 肝移植 / 温粗血時間
Research Abstract	Liver transplant outcomes using grafts donated after cardiac death (DCD) remain poor. Our goal of this study was to extend the warm ischemic time in rat liver transplantation from DCD donors. For this purpose, it is important to control the ischemic/reperfusion (I/R) injury after transplantation. There are a couple of reports to prevent I/R injury, and we applied venous systemic oxygen persufflation (VSOP) and nitric oxide (NO) gas administration. Using rat liver transplantation models from 60 minutes DCD donors, VSOP-NO treatment could effectively decreasing the damage of I/R injury, leading to the better survival. However, we failed to extend the warm ischemic time by this methods. There may be a limitation in these graft reconditioning procedures, further investigation to understand this phenomena is required.