2012 Fiscal Year Final Research Report
A new model for studies of microenvironment in hepatocellular cancerusing 4-dimensional intravital microscopy and the inhibition of the development and themetastasis of HCC.
| Project/Area Number |
22591410
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
INOMATA Yukihiro 熊本大学, 大学院・生命科学研究部, 教授 (50193628)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAMOTO Hidekazu 熊本大学, 医学薬学研究部, 助教 (10378101)
LEE Kwang-jong 熊本大学, 医学部附属病院, 助教 (00467995)
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| Research Collaborator |
HONDA Masaki 熊本大学, 医学部附属病院, 病院教員
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| Project Period (FY) |
2010 – 2012
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| Keywords | 肝癌 / 移植 / 蛍光顕微鏡 / 微小環境 |
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| Research Abstract |
We describe the use of 4D intravital microscopy which represents an advantageous technologyfor the investigation of the microvascular system and leukocyte migration in HCC. Weshowed that although vessel density in HCC was lower than in normal liver, tumor tissuewas moderately infiltrated with leukocytes. Most tumor-infiltrating leukocytes migratedin a random manner frequently changing direction of migration in the tumor tissue
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