Preoperative chemo-radiation therapy for rectal cancer by analysis of chemo-radiation sensitizing gene expression

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591414
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Wakayama Medical University
• Principal Investigator: HOTTA Tsukasa 和歌山県立医科大学, 医学部, 講師 (50244744)
• Co-Investigator(Kenkyū-buntansha): YAMAUE Hiroki 和歌山県立医科大学, 医学部, 教授 (20191190) ; TAKIFUJI Katsunari 和歌山県立医科大学, 医学部, 講師 (00254540) ; YOKOYAMA Shozo 和歌山県立医科大学, 医学部, 助教 (90398462) ; NAKAMURA Masaki 和歌山県立医科大学, 医学部, 助教 (80364090) ; MATSUDA Kenji 和歌山県立医科大学, 医学部, 助教 (30398458)
• Project Period (FY): 2010 – 2012
• Keywords: 外科総論

Research Abstract

This study tried to demonstrate the effect of chemo-radiation therapy for 24 patients with rectal cancer including 13 high sensitive patients for chemo-radiation (high sensitive group) and 11 low sensitive patients for chemo-radiation (low sensitive group) as to analysis of chemo-radiation sensitizing gene expression. Twelve of 13 patients in high sensitive group resulted in down stage, whereas 10 of 11 patients in low sensitive group resulted in down stage. Eleven of 13 patients in high sensitive group resulted in group1 for colonoscopic biopsy after chemo-radiation, whereas 2 of 11 patients in low sensitive group resulted in group1. Four of 13 patients in high sensitive group resulted in histopathological complete cure in excised organ after surgery. There were extramural cancer deposits without lymph node structures in 2 of 13 patients in high sensitive group, whereas 7 of 11 patients in low sensitive group. It was not clear of the effect of chemo-radiation sensitizing gene expression.