2012 Fiscal Year Final Research Report
Development of novel therapy targeting IL-17 in tumor microenvironment
| Project/Area Number |
22591415
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
IWAHASHI Makoto 和歌山県立医科大学, 医学部, 准教授 (70244738)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAUE Hiroki 和歌山県立医科大学, 医学部, 教授 (20191190)
OJIMA Toshiyasu 和歌山県立医科大学, 医学部, 助教 (20191190)
NAKAMURA Masaki 和歌山県立医科大学, 医学部, 講師 (20191190)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 外科総論 |
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| Research Abstract |
MC38 or B16 cells were inoculated subcutaneously into mice, and intratumoral injection of an adenovirus vector expressing siRNA against the mouse IL-17A gene (Ad-si-IL-17) significantly inhibited tumor growth in both tumor models compared with control mice. Blockade of IL-17A at tumor sites helped suppress tumor growth by inhibiting angiogenesis as well as activating antitumor immunity at tumor sites
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[Journal Article] Inhibition of IL-17A in tumor microenvironment augments cytotoxicity of tumor-infiltrating lymphocytes in tumor-bearing mice2013
Author(s)
Hayata K, Iwahashi M, Ojima T, Katsuda M, Iida T, Nakamori M, Ueda K, Nakamura M, Miyazawa M, Tsuji T,Yamaue H
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Journal Title
DOI
Peer Reviewed
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