2012 Fiscal Year Final Research Report
Elucidation of the biological properties of triple negative breast cancer and construction of a therapeutic strategy
| Project/Area Number |
22591421
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
ISHIDA Takanori 東北大学, 大学院・医学系研究科, 准教授 (00292318)
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| Co-Investigator(Kenkyū-buntansha) |
OHCHI Noriaki 東北大学, 大学院・医学系研究科, 教授 (90203710)
AMARI Masakazu 東北大学, 大学院・医学系研究科, 准教授 (50400312)
WATANABE Mika (渡辺 みか) 東北大学, 病院, 准教授 (20292344)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYASHITA Minoru 東北大学, 病院, 助教 (60710788)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 乳癌 / トリプルネガティブ / リスクスコア |
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| Research Abstract |
Triple negative breast cancer observed high histological grade, further vascular invasion, high vascularization and proliferation potential. Results of our study demonstrated that triple negative breast cancer could be further sub-classified into three different groups (low, intermediate, high) according to the Risk Score System evaluating the following five prognostic variable (pathological tumor size, pathological node status, basal-like type, Ki67 labeling index and Microvessel Density). Difference was observed in the survival rate significantly in these three groups. In conclusion, this classification is useful as a therapeutic decision-making tool for triple negativepatients.
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Research Products
(10 results)
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[Journal Article] Androgenic pathway in triple negative invasive ductal tumours: its correlation with tumour cell proliferation. Cancer Sci2013
Author(s)
McNamara K, Yoda T, Miki Y, Chanplakorn N, Wongwaisayawan S, Incharoen P, Kongdan Y, Wang L, Takagi K, Mayu T, Nakamura Y, Suzuki T, Nemoto N, Miyashita M, Tamaki K, Ishida T, Ohuchi N, Sasano H
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Journal Title
DOI
Peer Reviewed
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[Journal Article] Analysis of clinically relevant values of Ki-67 labeling index in Japanese breast cancer patients. Breast Cancer2012
Author(s)
Tamaki K, Ishida T, Tamaki N, Kamada Y, Uehara K, Miyashita M, Amari M, Tadano-Sato A, Takahashi Y, Watanabe M, McNamara K, Ohuchi N, Sasano H.
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Journal Title
There is peer review.
Pages: PMID:22782361
URL
Peer Reviewed
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