2012 Fiscal Year Final Research Report
The responsiveness of ALDH1-positive cells to chemotherapy in metastatic lesions and its prognostic significance in patients with breast cancer
| Project/Area Number |
22591423
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAGASHIMA Takeshi 千葉大学, 医学部附属病院, 講師 (60292710)
MIYAZAKI Masaru 千葉大学, 大学院・医学研究院, 教授 (70166156)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 乳腺外科学 |
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| Research Abstract |
In this study, the responsiveness of ALDH1-positive cells to chemotherapy in primary and metastatic lesions and its associated prognostic significance were revealed in patients with breast cancer. ALDH1-positive cells may represent a surrogate marker as a new concept in patients with lymph node-positive breast cancer. In the future, ALDH1-positive cells may be used for diagnosis and treatment, and these cell populations could be targeted in the development of new chemotherapies. We hope that our results will provide basic data for therapies targeting cell subpopulations in tumors,rather than the whole body, in patients with noncurable, metastatic breast cancer.
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