Prevention ofhepatocellularcarcinoma development through inhibition of AP-1 by EGCG

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591428
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Nagoya University
• Principal Investigator: FUJII Tsutomu 名古屋大学, 医学部附属病院, 助教 (60566967)
• Co-Investigator(Kenkyū-buntansha): SUGIMOTO Hiroyuki 名古屋大学, 大学院・医学系研究科, 講師 (20437007) ; NOMOTO Shuji 名古屋大学, 医学部附属病院, 病院講師 (40300967) ; KASUYA Hideki 名古屋大学, 大学院・医学系研究科, 准教授 (00402636) ; TAKEDA Shin 名古屋大学, 大学院・医学系研究科, 准教授 (20314015) ; NAKAO Akimasa 名古屋大学, 大学院・医学系研究科, 教授 (70167542)
• Project Period (FY): 2010 – 2012
• Keywords: EGCG / AP-1 / EGF / 肝細胞癌

Research Abstract

In the liver cancer tissue of EGF transgenic mice, the increased expression of c-jun and activity of AP-1 were shown to increase. In addition, the intraabdominal administration of EGCG suppressed hepatocarcinogenesis. These in vivoresults were similar to in vitroones that we revealed previously. Furthermore, when we examined the signaling pathways of human liver cancer tissue, the recurrence-free survival in patients with higher expression of c-Jun was significantly lower than that in patients with lower expression of c-jun.

Research Products

• [Journal Article] Identification of the A Kinase Anchor Protein 12 (AKAP12) Gene as a Candidate Tumor Suppressor of Hepatocellular Carcinoma (2012)
  • Author(s): Masamichi Hayashi, Shuji Nomoto, Mitsuro Kanda, Yukiyasu Okamura, Yoko Nishikawa, Suguru Yamada, Tsutomu Fujii, Hiroyuki Sugimoto, Shin Takeda, Yasuhiro Kodera
  • Journal Title: ournal of Surgical Oncology Volume: Vol.105 No.4 Pages: 381-386
  • Peer Reviewed
• [Journal Article] Mouse model of carbon tetrachloride induced liver fibrosis: Histopathological changes and expression of CD133 and epidermal growth factor (2010)
  • Author(s): Tsutomu Fujii, Bryan C Fuchs, SuguruYamada, Gregory Y Lauwers, Yakup Kulu, Jonathan M Goodwin, Michael Lanuti, Kenneth K Tanabe
  • Journal Title: BMC Gastroenterology Volume: Vol.10 Pages: 79
  • Peer Reviewed
• [Presentation] Epithelial to Mesenchymal Transition (EMT) in Pancreatic Cancer (2012)
  • Author(s): Tsutomu Fujii, Suguru Yamada, Masaya Suenaga, Norio Okumura, Daisuke Kobayashi, Chie Tanaka, Goro Nakayama, Hiroyuki Sugimoto, Masahiko Koike, Shuji Nomoto, Michitaka Fujiwara, Shin Takeda, Yasuhiro Kodera
  • Organizer: The Joint 43rd Meeting of the American Pancreatic Association and the 17th Meeting of the International Association of Pancreatology
  • Place of Presentation: Miami, Florida
  • Year and Date: 2012-11-02
• [Presentation] EGFR Inhibition Prevents Cirrhosis and Hepatocellular Carcinoma (2011)
  • Author(s): Bryan C. Fuchs1, Yujin Hoshida, Tsutomu Fujii, Suguru Yamada, Gregory Y. Lauwers, Christopher M. McGinn, Lan Wei, Toshihiko Kuroda, Michael Lanuti, Supriya Gupta, Andrew Crenshaw, Robert Onofrio, Bradley Taylor, Wendy Winckler, Todd R. Golub, Kenneth K. Tanabe
  • Organizer: AASLD (The American Association for the Study of Liver Diseases) 62nd Annual Meeting and Postgraduate CourceThe - Liver Meeting 2011
  • Place of Presentation: San Francisco, California
  • Year and Date: 2011-11-08
• [Presentation] CCl4 肝線維化マウスモデルに対する Erlotinib による抑制効果の検討 (2010)
  • Author(s): 山田 豪,F.C. Bryan,藤井 努,T.K. Kenneth,中尾 昭公
  • Organizer: 第15回日本肝臓学会大会
  • Place of Presentation: 福岡(マリンメッセ福岡
  • Year and Date: 2010-10-21