Combined therapy using drug resistant relative molecular-suppressing vector and anticancer drug

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591435
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Kagawa University
• Principal Investigator: LIU Dage 香川大学, 医学部, 助教 (30314941)
• Co-Investigator(Kenkyū-buntansha): YOKOMISE Hiroyasu 香川大学, 医学部, 教授 (80231728) ; UENO Masaki 香川大学, 医学部, 助教授 (30322267)
• Project Period (FY): 2010 – 2012
• Keywords: 非小細胞肺癌 / 薬剤耐性 / 抗腫瘍剤増感法 / 抑制ベクター / shRNA / 進行期肺癌

Research Abstract

（No Summary）

Research Products

• [Journal Article] Biomarkers as prognostic factors for cN2 or 3 non-small cell lung cancer treated by induction chemoradiotherapy and surgery (2013)
  • Author(s): Yokomise H, Liu D, Chang S, Go T, Ishikawa S, Misaki N, Nakashima N
  • Journal Title: Anticancer Res Volume: 33(3) Pages: 1107-15
• [Journal Article] Adenoviral vector expressing short hairpin RNA targeting Wnt2B has an effective antitumour activity against Wnt2B2-overexpressing tumours (2012)
  • Author(s): Liu D, Kadota K, Ueno M, Nakashima N, Yokomise H, Huang CL
  • Journal Title: Eur J Cancer Volume: 48(8) Pages: 1208-18
• [Journal Article] Wnt3 gene expression promotes tumor progression in non-small cell lung cancer (2012)
  • Author(s): Nakashima N, Liu D, Huang CL, Ueno M, Zhang X, Yokomise H
  • Journal Title: Lung Cancer Volume: 76(2) Pages: 228-34
• [Journal Article] Combined therapy with a thymidylate synthase-inhibiting vector and S-1 has effective antitumor activity against 5-FU-resistant tumors (2011)
  • Author(s): Kadota K, Huang CL, Liu D, Yokomise H, Haba R, Wada H
  • Journal Title: Int J Oncol Volume: 38(2) Pages: 355-63
• [Journal Article] Intratumoral Wnt1 expression affects survivin gene expression in non-small cell lung cancer (2010)
  • Author(s): Nakashima N, Huang CL, Liu D, Ueno M, Yokomise H
  • Journal Title: Int J Oncol. Volume: 9 Pages: 687-694
• [Presentation] 非小細胞肺癌における新規 p53 標的遺伝子 DNA polymerase ?(PolH)発現の臨床意義 (2012)
  • Author(s): 劉大革, 新居和人, 張霞, 徳永義昌, 中島成泰,石川真也. 横見瀬裕保
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌市
  • Year and Date: 2012-09-19
• [Presentation] 肺腺癌術後症例におけるバイオマーカーの検索及び術後治療効果との関連. (2012)
  • Author(s): 劉 大革, 中島 成泰, 新居 和人, 松浦奈津美, 笠井 由隆, 後藤 正司, 垂水 晋太郎, 張 性洙, 石川真也, 呉 哲彦, 黄 政龍, 横見瀬 裕保.
  • Organizer: 第112回日本外科学会定期学術集会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2012-04-13
• [Presentation] Biomarkers as Prognostic Factors for cN2,3 Non-Small Cell Lung Cancer Treated by Induction Chemoradiotherapy and Surgery (2012)
  • Author(s): Yokomise H, Liu D, Chang SS, Goto T, Ishikawa S, Misaki N, Nakashima N
  • Organizer: STS 48th Annual Meeting
  • Place of Presentation: Fort Lauderdale, FL, USA
  • Year and Date: 2012-01-30
• [Presentation] Wnt2B-suppressing adenoviral vector has a significant antitumor activity against Wnt2B-overexpressing tumors. (2011)
  • Author(s): 劉大革、黄 政龍、中島成泰、新居和人、石川真也、横見瀬裕保
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-03
• [Presentation] 術後抗癌剤治療を行ったpN2 肺癌症例における腫瘍内 ERCC1、ClassIIIβtubulin 発現と予後に関する検討 (2011)
  • Author(s): 松浦奈都美、中島成泰、垂水晋太郎、張性洙、三崎伯幸、 劉大革、呉哲彦、石川真也、横見瀬裕保.
  • Organizer: 第28回日本呼吸器外科学会総会
  • Place of Presentation: 別府ビーコンプラザ
  • Year and Date: 2011-05-13
• [Presentation] 肺腺癌術後症例におけるバイオマーカーの検索及び予後。 (2011)
  • Author(s): 劉大革、垂水晋太郎、松浦奈都美、中島成泰、張性洙、三_伯幸、呉哲彦、石川真也、黄政龍、横見瀬裕保
  • Organizer: 第28回日本呼吸器外科学会総会
  • Place of Presentation: 別府ビーコンプラザ
  • Year and Date: 2011-05-13
• [Presentation] 非小細胞肺癌におけるWnt2B の c-Myc 発現誘導とその臨床意義 (2010)
  • Author(s): 劉大革、垂水晋太郎、松浦奈都美、中島成泰、張性洙、三_伯幸、呉哲彦、石川真也、黄政龍、横見瀬裕保
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場 (大阪府)
  • Year and Date: 2010-09-23