2012 Fiscal Year Final Research Report
The role of cathepsin E in mammary carcinogenesis and prognosis in breast cancer
| Project/Area Number |
22591438
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Nagoya City University |
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Principal Investigator |
SUGIURA Hiroshi 名古屋市立大学, 大学院・医学研究科, 研究員 (20381882)
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| Co-Investigator(Kenkyū-buntansha) |
TOYAMA Tatsuya 名古屋市立大学, 大学院・医学研究科, 准教授 (30315882)
YAMASHITA Hiroko 北海道大学, 大学院・医学研究科, 教授 (70332947)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWAKUBO Tomoyo 九州大学, 大学院・薬学研究院, 特任助教 (70507813)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 乳癌 / カテプシン E / 予後因子 |
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| Research Abstract |
Cathepsin E an endosomal aspartic proteinase associated with immune responses. The serum cathepsin E activity was significantly decreased according to the stages and progression in breast cancer, and was significantly associated with disease-free and overall survival. Cathepsin E-deficient mice frequently and age-dependently developed mammary tumors. Cathepsin E controls proper trafficking and secretion of Wnt5a that triggers normal growth and development of mammary glands, representing a novel mechanism whereby cathepsin E can inhibit mammary carcinogenesis.
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