2012 Fiscal Year Final Research Report
Novel biomarker for the prediction of tamoxifen treatment in ER positive breast cancer
| Project/Area Number |
22591442
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHIDA Tetsu 慶應義塾大学, 医学部, 助教 (80327543)
TAKAHASHI Maiko 慶應義塾大学, 医学部, 助教 (50348661)
SAKATA Michio 慶應義塾大学, 医学部, 助教 (60235158)
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| Project Period (FY) |
2010 – 2012
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| Keywords | BTG2 / 乳癌 / 内分泌療法 / 薬剤感受性 |
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| Research Abstract |
Based on previous results, we analyzed if BTG2 expression affects the sensitivity against tamoxifen. Tetracycline-inducible BTG2 expression model in MCF7 was developed to assess the cytotoxicity by tamoxifen treatment in vitro and in vivo. Tumor growth ra
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