2012 Fiscal Year Final Research Report
Analysis of the tumor biological factor regulating the antibody-delivery
| Project/Area Number |
22591447
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
YASUNAGA Masahiro 独立行政法人国立がん研究センター, 臨床開発センター, ユニット長 (80450576)
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| Research Collaborator |
MATSUMURA Yasuhiro 独立行政法人国立がん研究センター, 臨床開発センター, 分野長 (90209619)
MANABE Shino 独立行政法人理化学研究所, 伊藤細胞制御化学, 専任研究員 (60300901)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 抗体デリバリー / 抗体 / ADC / DDS / 間質バリア / 膵臓がん / 悪性リンパ種 / SN-38 |
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| Research Abstract |
In pancreatic cancer as a refractory solid tumor, tumor stromal barrier interferes with antibody-delivery. To improve the delivery and maximize the therapeutic effect of antibody drug conjugate (ADC) against such tumors, it is important to determine the most appropriate drug design e.g. combination of the anti-stroma antibody and the linker for the drug-release outside the cells. On the other hand, cell-targeting ADC is effective against malignant lymphoma as a stroma-poor tumor without the interference of antibody-delivery. In this type of ADC, an antibody having a high cell-internalization efficacy should be selected.
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[Presentation] 間質ターゲット2010
Author(s)
安永正浩、眞鍋史乃、松村保広
Organizer
日本生体医工学学会ナノメディシンフォーラム
Place of Presentation
東京慈恵会医科大学
Year and Date
2010-09-04
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