2012 Fiscal Year Final Research Report
A novel diagnostic method using C-reactive protein genetic polymorphism in patients with thoracic esophageal cancer and its mechanisms
| Project/Area Number |
22591448
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Akita University |
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Principal Investigator |
MOTOYAMA Satoru 秋田大学, 大学院・医学系研究科, 教授 (60292372)
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| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Kiyotomi 秋田大学, 医学部, 講師 (80361228)
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| Project Period (FY) |
2010 – 2012
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| Keywords | C反応性蛋白 / リンパ節転移 |
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| Research Abstract |
We inoculated subcutaneously NR-S1M metastatic cells into the backs of C3H/HeN mice. Concurrently, 1 μg of recombinant mouse CRP or PBS were injected subcutaneously every 3 days for 5 weeks, after which the mice were killed for evaluation. We evaluated lymph node metastasis and lymphangiogenesis in the implanted tumor using immunohistochemical analysis with anti-lymphatic vessel endothelial hyaluronan receptor-1 antibodies. Immunohistochemical analysis confirmed inguinal lymph node metastasis in 70% of control mice, but in only 30% of mice in the CRP group. Moreover, tumoral lymphangiogenesis was decreased in the CRP group). CRP appears to inhibit tumoral lymphangiogenesis and lymph node metastasis in mice.
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[Journal Article] Evaluation of the risk of lymph node metastasis using CRP 1846C>T genetic polymorphism in submucosal thoracic esophageal squamous cell carcinoma
Author(s)
Motoyama S, Mori K, Kamei T, Miura M, Hinai Y, SatoY, Yoshino K, Sasaki T, Miyata G, Seto Y, Ogawa J
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Journal Title
Ann Surg Oncol
Volume: 20
Pages: 1978-1984(4.166)
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