2012 Fiscal Year Final Research Report
The study of the mechanism of Wnt signal in the gastric cancer stem cell and the application to the cancer therapy.
| Project/Area Number |
22591453
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
TANABE Kazuaki 広島大学, 大学院・医歯薬保健学研究院, 講師 (40379847)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Takahisa 広島大学, 病院, 病院助教 (80467779)
TOKUMOTO Noriaki 広島大学, 病院, 病院助教 (90564980)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 胃十二指腸外科学 / 癌幹細胞 |
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| Research Abstract |
This study was originally planned to comfirm the specific marker for gastric cancer stem cell. In the study, we found that CD24 is one of factor of malignant potential in gastric cancer. Up-regulation of CD24 results the up-regulation of both adhesion and invasion. Furthermore, CD24 is more expressed under hypoxic condition compare to normoxia. We found that HIFs take apart in the induction of the CD24 expression. CD24 plays important rolls in gastric cancer invasion.
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