2012 Fiscal Year Final Research Report
The clinical significance of serum diamine oxidase(DAO) activity during chemotherapy in patients with carcinoma
| Project/Area Number |
22591455
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Yamaguchi University |
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Principal Investigator |
TAKEDA Shigeru 山口大学, 大学院・医学系研究科, 助教 (50403671)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHINO Shigefumi 山口大学, 医学部附属病院, 准教授 (60294633)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 食道 |
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| Research Abstract |
DAO activities in the patients having GI toxicity significantly decreased on day 7 (p<0.01), and recovered to the level of pre-chemotherapy on day 28. In contrast, DAO activities in patients without GI toxicity did not change during chemotherapy. Serum DAO activity may be a sensitive biomarker of GI toxicity, and be useful to predict the risk of GI toxicity in esophageal cancer patients during chemotherapy.Enteral supplementation (GFO) is useful for preventing gastrointestinal toxicity during chemotherapy in patients with esophageal carcinoma.
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