2012 Fiscal Year Final Research Report

The mobilization and recruitment of endothelial progenitor cells contribute to acceleration of tumor growth after surgery

Research Project

Project/Area Number	22591456
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Digestive surgery
Research Institution	Yamaguchi University
Principal Investigator	ENOKI Tadahiko 山口大学, 大学院・医学系研究科, 大学院医学系研究科 (80311819)
Co-Investigator(Kenkyū-buntansha)	UEDA Kazuhiro 山口大学, 医学部附属病院, 講師 (90420520)
Research Collaborator	TAKEMOTO Yoshihiro 山口大学, 医学部附属病院, 助教 (50622213)
Project Period (FY)	2010 – 2012
Keywords	手術侵襲 / 血管内皮前駆細胞
Research Abstract	Using an established tumor model in mice, we performed open gastrotomy. After gastrotomy, the tumor volume was almost double in mice, and then the number of bone marrow-derived stem cells (BMSCs) found in tumor tissue significantly increased in mice. Furthermore, administration of AMD3100, a known as CXCR4 antagonist significantly inhibited the recruitment of BMSCs and negated the acceleration in tumor growth after surgery. In clinical practice, we examined the recruitment of BMSCs and the concentration of VEGF in the peripheral blood after surgery in gastric cancer patients. The concentration of VEGF in the peripheral blood was higher than that before surgery, whereas the recruitment of BMSCs to the peripheral blood after surgery didn’t increase.