Biological analysis of microenvironment associated with lymphangiogenesis in gastrointestinal cancer

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591460
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kagoshima University
• Principal Investigator: MATSUMOTO Masataka 鹿児島大学, 大学院・医歯学総合研究科, 客員研究員 (40398293)
• Co-Investigator(Kenkyū-buntansha): UCHIKADO Yasuto 鹿児島大学, 医学部・歯学部付属病院, 助教 (30464465) ; KITA Yoshiaki 鹿児島大学, 医学部・歯学部付属病院, 特任助教 (30570692) ; NATSUGOE Shoji 鹿児島大学, 医歯学総合研究科, 教授 (70237577) ; ISHIGAMI Sumiya 鹿児島大学, 医学部・歯学部付属病院, 講師 (90325803)
• Project Period (FY): 2010 – 2012
• Keywords: リンパ管新生 / 血管新生 / 微小環境 / 消化器癌

Research Abstract

VEGF-C and VEGF-D induced lymphangiogenesis followed by the lymph node metastasis. And the lymphangiogenesis occurred also in the lymph nodes as well as primary tumor. In the cancer microenvironment, CD133, CD166, E-cadherin, Slug, BMP-7,and regulatory T cell were closely related to lymphatic invasion and lymph node metastasis.

Research Products

• [Journal Article] Assessment of sentinel node concept in esophageal cancer based on lymph node micrometastasis (2013)
  • Author(s): Hagihara T, Uenosono Y, Arigami T, Kozono T, Arima H, Yanagita S, Hirata M, Ehi K, Okumura H, Matsumoto M, Uchikado Y, Ishigami S, Natsugoe S
  • Journal Title: Ann Surg Oncol Volume: 20(印刷中)
  • Peer Reviewed
• [Journal Article] Signaling for lymphangiogenesis via VEGFR-3 is required for the early events Masataka Matsumoto of metastasis (2013)
  • Author(s): Matsumoto M, Roufail S, Inder R, Caesar C, Karnezis T, Shayan R, Farnsworth RH, Sato T, Achen MG, Mann GB, Stacker SA
  • Journal Title: Clin Exp Metastasis Volume: 30(印刷中)
  • Peer Reviewed
• [Journal Article] Clinical significance of (18)F-fluorodeoxyglucose positron emission tomography in superficial esophageal squamous cell carcinoma (2013)
  • Author(s): Kita Y, Okumura H, Uchikado Y, Sasaki K, Omoto I, Matsumoto M, Setoyama T, Tanoue K, Mori S, Owaki T, Ishigami S, Ueno S, Kajiya Y, Natsugoe S
  • Journal Title: Ann Surg Oncol Volume: 20 Pages: 1646-1652
  • Peer Reviewed
• [Journal Article] Serum concentrations of antibiotics during severe invasive surgery such as esophagectomy for esophageal cancer (2013)
  • Author(s): Owaki T, Okumura H, Uchikado Y, Sasaki K, Matsumoto M, Omoto I, Setoyama T, Kita Y, Sakurai T, Matsushita D, Ishigami S, Ueno S, Natsugoe S
  • Journal Title: Int Surg Volume: 98 Pages: 1-5
  • Peer Reviewed
• [Journal Article] Clinical significance of lymph node micrometastasis in gastric cancer (2013)
  • Author(s): Arigami T, Uenosono Y, Yanagita S, Nakajo A, Ishigami S, Okumura H, Kijima Y, Ueno S, Natsugoe S
  • Journal Title: Ann Surg Oncol Volume: 20 Pages: 515-521
  • Peer Reviewed
• [Journal Article] Endoscopic ultrasonography is useful for monitoring the tumor responseof neoadjuvant chemoradiation therapy in esophageal squamous cell carcinoma (2012)
  • Author(s): Owaki T, Matsumoto M, Okumura H, Uchikado Y, Kita Y, Setoyama T, SasakiK, Sakurai T, Omoto I, Shimada M, Sakamoto F, Yoshinaka H, Ishigami S, Ueno S, Natsugoe S
  • Journal Title: Am J Surg Volume: 203 Pages: 191-197
  • Peer Reviewed
• [Journal Article] Mesothelin expression correlates with prolonged patient survival in gastric cancer (2012)
  • Author(s): Baba K, Ishigami S, Arigami T, Uenosono Y, Okumura H, Matsumoto M, Kurahara H, Uchikado Y, Kita Y, Kijima Y, Kitazono M, Shinchi H, Ueno S, Natsugoe S
  • Journal Title: J Surg Oncol Volume: 105 Pages: 195-199
  • Peer Reviewed
• [Journal Article] Clinicopathological significance of BMP7 expression in esophageal squamous cell carcinoma (2012)
  • Author(s): Megumi K, Ishigami S, Uchikado Y, Kita Y, Okumura H, Matsumoto M, Uenosono Y, Arigami T, Kijima Y, Kitazono M, Shinchi H, Ueno S, Natsugoe S
  • Journal Title: Ann Surg Oncol Volume: 19 Pages: 2066-2071
  • Peer Reviewed
• [Journal Article] Prognostic factors in esophageal squamous cell carcinoma patients treated with neoadjuvant chemoradiation therapy (2012)
  • Author(s): Okumura H, Uchikado Y, Matsumoto M, Owaki T, Kita Y, Omoto I, Sasaki K, Sakurai T, Setoyama T, Nabeki B, Matsushita D, Ishigami S, Hiraki Y, Nakajo M, Natsugoe S
  • Journal Title: Int J Clin Oncol Volume: 18 Pages: 329-334
  • Peer Reviewed
• [Journal Article] Clinical implications of N-cadherin expression in gastric cancer (2012)
  • Author(s): Kamikihara T, Ishigami S, Arigami T, Matsumoto M, Okumura H, Uchikado Y, Kita Y, Kurahara H, Kijima Y, Ueno S, Natsugoe S
  • Journal Title: Pathol Int Volume: 62 Pages: 161-166
  • Peer Reviewed
• [Journal Article] Cancerous HLA class I expression and regulatory T cell infiltration in gastric cancer (2012)
  • Author(s): Ishigami S, Arigami T, Uenosono Y, Matsumoto M, Okumura H, Uchikado Y, Kita Y, Nishizono Y, Maemura K, Kijima Y, Nakajo A, Owaki T, Ueno S, Hokita S, Natsugoe S
  • Journal Title: Cancer Immunol Immunother Volume: 61 Pages: 1663-1669
  • Peer Reviewed
• [Journal Article] Expression of BMP-7 in human gastric cancer and its clinical significance (2011)
  • Author(s): Aoki M, Ishigami S, Uenosono Y, Arigami T, Uchikado Y, Kita Y, Kurahara H, Matsumoto M, Ueno S, Natsugoe S
  • Journal Title: Br J Cancer Volume: 104 Pages: 714-718
  • Peer Reviewed
• [Journal Article] Increased Slug and decreased E-cadherin expression is related to poor Prognosis in patients with gastric cancer (2011)
  • Author(s): Uchikado Y, Okumura H, Ishigami S, Setoyama T, Matsumoto M, Owaki T, Kita Y, Natsugoe S
  • Journal Title: Gastric Cancer Volume: 14 Pages: 41-49
  • Peer Reviewed
• [Journal Article] Prognostic impact of CD168 expression in gastric cancer (2011)
  • Author(s): Ishigami S, Ueno S, Nishizono Y, Matsumoto M, Kurahara H, Arigami T, Uchikado Y, Setoyama T, Arima H, Kita Y, Kijima Y, Kitazono M, Natsugoe S
  • Journal Title: BMC Cancer Volume: 11 Pages: 106
  • Peer Reviewed
• [Journal Article] entinel node navigation surgery is acceptable for clinical T1 and N0 esophageal cancer (2011)
  • Author(s): Uenosono Y, Arigami T, Yanagita S, Kozono T, Arima H, Hirata M, Kita Y, Uchikado Y, Okumura H, Matsumoto M, Natsugoe S
  • Journal Title: Ann Surg Oncol Volume: 18 Pages: 2003-2009
  • Peer Reviewed
• [Journal Article] Esophageal squamous cell carcinoma co-existing with achalasia: report of two cases (2011)
  • Author(s): Matsumoto M, Uchikado Y, Kita Y, Omoto I, Setoyama T, Okumura H, Owaki T, Ishigami S, Ueno S, Natsugoe S
  • Journal Title: Esophagus Volume: 8 Pages: 131-136
  • Peer Reviewed
• [Journal Article] 食道表在癌の術前診断および Sentinel Node Navigation を応用した外科治療 (2011)
  • Author(s): 松本正隆,上之園芳一,有上貴明,内門泰斗,喜多芳昭,尾本 至,大脇哲洋,石神純也,夏越祥次
  • Journal Title: 日本気管食道科学会会報 Volume: 第62巻 Pages: 138-139
• [Journal Article] Prognostic value of CD208-positive cell infiltration in gastric cancer (2010)
  • Author(s): Ishigami S, Ueno S, Matsumoto M, Okumura H, Arigami T, Uchikado Y, Setoyama T, Arima H, Sasaki K, Kitazono M, Shinchi H, Kijima Y, Natsugoe S
  • Journal Title: Cancer Immunol Immunother Volume: 59 Pages: 389-395
  • Peer Reviewed
• [Journal Article] Clinical course and outcome after esophagectomy with three-field lymphadenectomy in esophageal cancer (2010)
  • Author(s): Natsugoe S, Matsumoto M, Okumura H, Uchikado Y, Setoyama T, Sasaki K, Sakurai T, Omoto I, Owaki T, Shinchi H, Ueno S, Ishigami S
  • Journal Title: Langenbecks Arch Surg Volume: 95 Pages: 341-346
  • Peer Reviewed
• [Journal Article] Prognostic impact of CD133 expression in gastric carcinoma (2010)
  • Author(s): Ishigami S, Ueno S, Arigami T, Uchikado Y, Setoyama T, Arima H, Kita Y, Kurahara H, Okumura H, Matsumoto M, Kijima Y, Natsugoe S
  • Journal Title: Anticancer Res Volume: 30 Pages: 2453-2457
  • Peer Reviewed
• [Journal Article] Significance of lymphangiogenesis in primary tumor and draining lymph nodes during lymphatic metastasis of pancreatic head cancer (2010)
  • Author(s): Kurahara H, Takao S, Shinchi H, Maemura K, Mataki Y, Sakoda M, Hayashi T, Kuwahata T, Minami K, Ueno S, Natsugoe S
  • Journal Title: J Surg Oncol Volume: 102 Pages: 809-815
  • Peer Reviewed
• [Journal Article] Clinical implication of CD166 expression in gastric cancer (2010)
  • Author(s): Ishigami S, Ueno S, Arigami T, Arima H, Uchikado Y, Kita Y, Sasaki K, Nishizono Y, Omoto I, Kurahara H, Matsumoto M, Kijima Y, Natsugoe S
  • Journal Title: J Surg Oncol Volume: 103 Pages: 57-61
  • Peer Reviewed
• [Journal Article] Nuclear expression of 14-3-3 sigma is related to prognosis in patients with esophageal squamous cell carcinoma (2010)
  • Author(s): Okumura H, Kita Y, Yokomakura N, Uchikado Y, Setoyama T, Sakurai H, Omoto I, Matsumoto M, Owaki T, Ishigami S, Natsugoe S
  • Journal Title: Anticancer Res Volume: 30 Pages: 5175-5179
  • Peer Reviewed
• [Journal Article] 胃・食道疾患-診断のめざましい進歩 臨床症状からの診断プロセス 食物通過障害 (2010)
  • Author(s): 松本正隆,夏越祥次
  • Journal Title: 臨床と研究 Volume: 第87巻 Pages: 37-40
• [Journal Article] 食道切除後再建術における血行再建の適応と手技 (2010)
  • Author(s): 松本正隆,内門泰斗,喜多芳昭,奥村 浩,大脇哲洋,夏越祥次
  • Journal Title: 手術 Volume: 第64巻 Pages: 1387-1390
• [Journal Article] 知っておきたい癌取扱い規約のポイント-日本と世界の違い-食道癌 (2010)
  • Author(s): 松本正隆,内門泰斗,喜多芳昭,尾本 至,奥村 浩,大脇哲洋,石神純也,夏越祥次
  • Journal Title: 外科治療 Volume: 第103巻 Pages: 436-442
• [Journal Article] 胸部食道癌に対する外科治療の限界 (2010)
  • Author(s): 松本正隆,内門泰斗,喜多芳昭,尾本 至,奥村 浩,大脇哲洋,石神純也,夏越祥次
  • Journal Title: 癌の臨床 Volume: 第56巻 Pages: 219-224
• [Presentation] 切除不能食道進行癌に対するステント治療 (2012)
  • Author(s): 松本正隆,内門泰斗,喜多芳昭,尾本 至,佐々木健,瀬戸山徹郎,奥村 浩,大脇哲洋,石神純也,柳 正和,帆北修一,夏越祥次
  • Organizer: 第65回日本胸部外科学会定期学術集会
  • Place of Presentation: 福岡市
  • Year and Date: 20121017-20
• [Presentation] 消化器癌に対するリンパ管新生の役割と分子標的治療 (2012)
  • Author(s): 松本正隆,尾本 至,内門泰斗,喜多芳昭,佐々木健,奥村 浩,大脇哲洋,石神純也,帆北修一,夏越祥次
  • Organizer: 第67回日本消化器外科学会総会
  • Place of Presentation: 富山市
  • Year and Date: 20120718-20
• [Presentation] MM 以深の cN0 食道表在癌に対する Sentinel node navigationを用いた内視鏡治療 (2012)
  • Author(s): 内門泰斗,松本正隆,奥村 浩,大脇哲洋,喜多芳昭,佐々木健,尾本 至,橋口照人,石神純也,夏越祥次
  • Organizer: 第66回日本食道学会学術集会
  • Place of Presentation: 軽井沢町
  • Year and Date: 20120621-22
• [Presentation] 食道癌におけるリンパ節微小転移を踏まえたSentinel Node 理論の検討 (2012)
  • Author(s): 萩原貴彦,上之園芳一,有上貴明,平田宗嗣,原口尚士,柳田茂寛,小園 勉,内門泰斗,松本正隆,奥村 浩,夏越祥次
  • Organizer: 第112回日本外科学会定期学術集会
  • Place of Presentation: 千葉市
  • Year and Date: 20120412-14
• [Presentation] 壁深達度 MM/SM1 の cN0食道表在癌に対する内視鏡的切除にSentinel node navigation を臨床応用した治療戦略 (2012)
  • Author(s): 内門泰斗,奥村 浩,上之園芳一,有上貴明,大脇哲洋,喜多芳昭,佐々木健,松本正隆,瀬戸山徹郎,石神純也,新地洋之,上野真一,夏越祥次
  • Organizer: 第74回日本臨床外科学会総会
  • Place of Presentation: 東京都
  • Year and Date: 2012-11-30
• [Presentation] 他臓器浸潤を伴う進行食道癌に対する治療 (2012)
  • Author(s): 松本正隆,内門泰斗,喜多芳昭,尾本 至,佐々木健,奥村 浩,大脇哲洋,石神純也,帆北修一,夏越祥次
  • Organizer: 他臓器浸潤を伴う進行食道癌に対する治療
  • Place of Presentation: 軽井沢町
  • Year and Date: 2012-06-22
• [Presentation] 他臓器浸潤食道癌に対する治療選択 (2011)
  • Author(s): 松本正隆,大脇哲洋,夏越祥次
  • Organizer: 第19回日本消化器関連学会週間
  • Place of Presentation: 福岡市
  • Year and Date: 2011-10-23
• [Presentation] Sentinel Node Navigationを応用した治療戦略 (2011)
  • Author(s): 松本正隆,大脇哲洋,夏越祥次
  • Organizer: 第19回日本消化器関連学会週間
  • Place of Presentation: 福岡市
  • Year and Date: 2011-10-22
• [Presentation] 高齢者食道癌に対する外科手術の諸問題と術式選択 (2011)
  • Author(s): 松本正隆,尾本 至,喜多芳昭,内門泰斗,瀬戸山徹郎,奥村 浩,大脇哲洋,石神純也,上野真一,夏越祥次
  • Organizer: 第66回日本消化器外科学会総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2011-07-14
• [Presentation] 食道癌に対する縦隔鏡補助下食道抜去術の適応と治療成績 (2010)
  • Author(s): 松本正隆,内門泰斗,喜多芳昭,尾本 至,惠 浩一,瀬戸山徹郎,奥村 浩,大脇哲洋,石神純也,夏越祥次
  • Organizer: 第23回日本内視鏡外科学会総会
  • Place of Presentation: 横浜市
  • Year and Date: 20102000
• [Presentation] 食道癌に対する縦隔鏡補助下食道抜去術のメリットとデメリット (2010)
  • Author(s): 松本正隆,内門泰斗,喜多芳昭,尾本 至,惠 浩一,瀬戸山徹郎,奥村 浩,大脇哲洋,石神純也,上野真一,夏越祥次
  • Organizer: 第72回日本臨床外科学会総会
  • Place of Presentation: 横浜市
  • Year and Date: 2010-11-21
• [Presentation] 食道表在癌の術前診断および Sentinel Node Navigation を応用した外科治療 (2010)
  • Author(s): 松本正隆,上之園芳一,有上貴明,内門泰斗,喜多芳昭,尾本 至,惠 浩一,瀬戸山徹郎,奥村 浩,大脇哲洋,石神純也,上野真一,夏越祥次
  • Organizer: 第62回日本気管食道科学会総会ならびに学術講演会
  • Place of Presentation: 別府市
  • Year and Date: 2010-11-04
• [Presentation] 食道癌における VEGF-C,VEGFR-3 発現とリンパ管新生 (2010)
  • Author(s): 尾本 至,松本正隆,奥村 浩,内門泰斗,瀬戸山徹郎,喜多芳昭,櫻井俊秀,佐々木健,大脇哲洋,石神純也,夏越祥次
  • Organizer: 第48回日本癌治療学会総会
  • Place of Presentation: 京都市
  • Year and Date: 2010-10-30
• [Presentation] High risk 食道癌に対する外科治療 (2010)
  • Author(s): 松本正隆,内門泰斗,喜多芳昭,尾本 至,惠 浩一,櫻井俊秀,佐々木健,瀬戸山徹郎,奥村 浩,大脇哲洋,石神純也,夏越祥次
  • Organizer: 第48回日本癌治療学会総会
  • Place of Presentation: 京都市
  • Year and Date: 2010-10-29
• [Presentation] 食道癌の術後再発治療における外科切除の役割 (2010)
  • Author(s): 松本正隆,内門泰斗,喜多芳昭,尾本 至,惠 浩一,櫻井俊秀,佐々木健,瀬戸山徹郎,奥村 浩,大脇哲洋,石神純也,夏越祥次
  • Organizer: 第63回日本胸部外科学会定期学術集会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-10-26
• [Presentation] Expression of Osteopontin in esophageal squamous cell carcinoma (2010)
  • Author(s): 喜多芳昭,奥村 浩,内門泰斗,松本正隆,瀬戸山徹郎,大脇哲洋,石神純也,新地洋之,上野真一,三森功士,森 正樹,夏越祥次
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-09-22
• [Presentation] Clinical significance of Stanniocalcin 2 expression in esophageal squamous cell carcinoma: identification of lymph node metastasis-specific genes using olionucleotide microarray (2010)
  • Author(s): Kita Y, Matsumoto M, Okumura H, Uchikado Y, Setoyama T, Ishigami S, Owaki T, Mimori K, Mori M, Natsugoe S
  • Organizer: 12th World Congress of the International Society of Diseases of the Esophagus
  • Place of Presentation: Kagoshima
  • Year and Date: 2010-09-04
• [Presentation] Surgical benefits for esophageal squamous cell carcinoma after radical esophagectomy with three-field lymphadenectomy (2010)
  • Author(s): Matsumoto M, Uchikado Y, Kita Y, Omoto I, Arigami T, Uenosono Y, Setoyama T, Okumura H, Owaki T, Ishigami S, Natsugoe S, Aikou T
  • Organizer: 2th World Congress of the International Society of Diseases of the Esophagus
  • Place of Presentation: Kagoshima
  • Year and Date: 2010-09-03
• [Presentation] A relationship between the Snail and Slug expression and prognosis in esophageal squamous cell carcinoma (2010)
  • Author(s): Uchikado Y, Matsumoto M, Okumura H, Setoyama T, Kita Y, Sasaki K, Sakurai T, Omoto I, Owaki T, Ishigami S, Ueno S, Natsugoe S
  • Organizer: 12th World Congress of the International Society of Diseases of the Esophagus
  • Place of Presentation: Kagoshima
  • Year and Date: 2010-09-03
• [Presentation] 食道癌に対するステント治療-特に気道内ステント留置について- (2010)
  • Author(s): 松本正隆,内門泰斗,喜多芳昭,尾本 至,瀬戸山徹郎,奥村 浩,大脇哲洋,石神純也,柳 正和,夏越祥次
  • Organizer: 第64回日本食道学会学術集会
  • Place of Presentation: 久留米市
  • Year and Date: 2010-08-31
• [Presentation] 術前合併症を有する胸部食道癌の術式選択 (2010)
  • Author(s): 松本正隆,内門泰斗,喜多芳昭,尾本 至,櫻井俊秀,瀬戸山徹郎,奥村 浩,大脇哲洋,石神純也,夏越祥次
  • Organizer: 第65回日本消化器外科学会総会
  • Place of Presentation: 下関市
  • Year and Date: 2010-07-15
• [Presentation] 食道表在癌における Osteopontin 発現の意義 (2010)
  • Author(s): 喜多芳昭,奥村 浩,内門泰斗,松本正隆,瀬戸山徹郎,大脇哲洋,石神純也,新地洋之,上野真一,夏越祥次
  • Organizer: 第110回日本外科学会定期学術集会
  • Place of Presentation: 名古屋市
  • Year and Date: 2010-04-10
• [Presentation] 食道癌における VEGF-C 発現とリンパ管新生 (2010)
  • Author(s): 尾本 至,松本正隆,奥村 浩,内門泰斗,瀬戸山徹郎,喜多芳昭,櫻井俊秀,佐々木健,大脇哲洋,石神純也,夏越祥次
  • Organizer: 第110回日本外科学会定期学術集会
  • Place of Presentation: 名古屋市
  • Year and Date: 2010-04-09
• [Presentation] 胸部食道癌に対する外科治療の限界 (2010)
  • Author(s): 松本正隆,内門泰斗,喜多芳昭,尾本 至,櫻井俊秀,瀬戸山徹郎,奥村 浩,大脇哲洋,石神純也,夏越祥次
  • Organizer: 第110回日本外科学会定期学術集会
  • Place of Presentation: 名古屋市
  • Year and Date: 2010-04-09