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2012 Fiscal Year Final Research Report

Therapeutic aspects from theanalysis of epithelial-mesenchymal transition (EMT) in gastric cancer.

Research Project

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Project/Area Number 22591469
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKeio University

Principal Investigator

WADA Norihito  慶應義塾大学, 医学部, 講師 (40256087)

Co-Investigator(Kenkyū-buntansha) TAKEUCHI Hiroya  慶應義塾大学, 医学部, 講師 (20265838)
HAYASHIDA Tetsu  慶應義塾大学, 医学部, 助教 (80327543)
Project Period (FY) 2010 – 2012
Keywords胃十二指腸外科学 / 胃癌 / 上皮間葉移行 / リンパ節転移 / HOXB9
Research Abstract

We have conducted our research in order to investigate the possibility of therapeutic application of the concept of epithelial-mesenchymal transition (EMT) for the treatment of advanced gastric cancer. Gastric cancer tissue from the patient treated in our

  • Research Products

    (29 results)

All 2013 2012 2011 2010 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (17 results) Book (3 results) Remarks (1 results)

  • [Journal Article] Clinical utility of the Revised Cardiac Risk Index in non-cardiac surgery for elderly patients: a prospective cohort study.2013

    • Author(s)
      Hirano Y, Takeuchi H, Suda K, Oyama T, Nakamura R, Takahashi T, Kawakubo H, Wada N, Saikawa Y, Obara H, Jinno H, Hasegawa H, Tanabe M, Kitagawa Y
    • Journal Title

      Surg Today

    • Peer Reviewed
  • [Journal Article] Adjuvant therapy with imatinib mesylate after resection of primary high-risk gastrointestinal stromal tumors in Japanese patients.2013

    • Author(s)
      Kanda T, Nishida T, Wada N, Kobayashi O,Yamamoto M, Sawaki A, Boku N, Koseki M, Doi T, Toh Y, Kakeji Y, Sugiyama T, Komatsu Y, Kikuchi S, Ogoshi K, Katai H, Miyachi K, Hirota S, Ohtsu A
    • Journal Title

      Int J Clin Oncol

      Volume: 18 Pages: 38-45

    • Peer Reviewed
  • [Journal Article] Antitumor effect of cetuximab in combination with S-1 in EGFR-amplified gastric cancer cells2012

    • Author(s)
      Fukuda K, Saikawa Y, Takahashi M, Takahashi T, Wada N, Kawakubo H, Takeuchi H, Kitagawa Y
    • Journal Title

      Int J Oncol

      Volume: 40 Pages: 975-982

    • Peer Reviewed
  • [Journal Article] Role of integrin α1 subunits in gastric cancer patients with peritoneal dissemination.2012

    • Author(s)
      Fukuda K, Saikawa Y, Yagi H, Wada N, Takahashi T, Kitagawa Y
    • Journal Title

      Mol Med Repor

      Volume: 5 Pages: 336-40

    • Peer Reviewed
  • [Journal Article] Laparoscopy-assisted proximal gastrectomy with sentinel node mapping for early gastric cancer.2011

    • Author(s)
      Takeuchi H, Oyama T, Kamiya S, Nakamura R, Takahashi T, Wada N, Saikawa Y, Kitagawa Y
    • Journal Title

      World J Surg

      Volume: 35 Pages: 2463-2471

    • Peer Reviewed
  • [Journal Article] Phase I study of neoadjuvant chemoradiotherapy consisting of S-1 and cisplatin for patients with resectable advanced gastric cancer (KOGC-01)2011

    • Author(s)
      Takahashi T, Saikawa Y, Takaishi H, Takeuchi H, Wada N, Oyama T, Fukuda K, Fukada J, Kawaguchi O, Shigematsu N, Kitagawa Y.
    • Journal Title

      Anticancer Res

      Volume: 31 Pages: 3079-3083

    • Peer Reviewed
  • [Journal Article] Feasibility and efficacy of combination chemotherapy with S-1 and fractional Cisplatin for advanced gastric cancer2010

    • Author(s)
      Takahashi T, Saikawa Y, Takaishi H, Takeuchi H, Wada N, Oyama T, Nakamura R, Kitagawa Y
    • Journal Title

      Anticancer Res

      Volume: 30 Pages: 3759-3762

    • Peer Reviewed
  • [Journal Article] Octreotide acetate enables the administration of chemoradiotherapy, including the oral anticancer drug S-1, in gastric cancer patients with malignant gastrointestinal obstruction2010

    • Author(s)
      Takahashi T, Saikawa Y, Igarashi T, Tsuwano S, Kumagai K, Nakamura R, Ooyama T, Wada N, Takeuchi H, Takaishi H, Kitagawa Y.
    • Journal Title

      Oncology Letters

      Volume: 1 Pages: 673-677

    • Peer Reviewed
  • [Presentation] Surgery Clinical significance of cancer cells in lymphatic vessels between primary tumor and sentinel nodes gastric cancer2012

    • Author(s)
      Takeuchi H. Gastric Cancer
    • Organizer
      10th International Conference of the Asian Clinical Oncology Society
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2012-06-14
  • [Presentation] Phase I study of preoperative chemoradiotherapy consisted of S-1 and cisplatin for patients with curable advanced gastric cancer (KOGC-01)2011

    • Author(s)
      Takahashi T
    • Organizer
      International Surgical Week
    • Place of Presentation
      Yokohama
    • Year and Date
      2011-08-29
  • [Presentation] Retrospective analysis for prognostic outcome of gastric cancer in young patients2011

    • Author(s)
      Nakamura R.
    • Organizer
      International Surgical Week
    • Place of Presentation
      Yokohama
    • Year and Date
      2011-08-29
  • [Presentation] The assessment of the procedure of the additional gastrectomy with sentinel node (SN) mapping after endoscopic submucosal dissection (ESD)2011

    • Author(s)
      Kamiya S
    • Organizer
      9th International Gastric Cancer Congress
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2011-04-22
  • [Presentation] Feasibility and efficacy of combination chemotherapy with S-1 and fractional cisplatin for advanced gastric cancer2011

    • Author(s)
      Wada T
    • Organizer
      9th International Gastric Cancer Congress
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2011-04-22
  • [Presentation] Long-term outcomes of laparoscopic wedge resection for gastrointestinal stromal tumor (GIST) of the stomach2011

    • Author(s)
      Wada N
    • Organizer
      9th International Gastric Cancer Congress
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2011-04-22
  • [Presentation] Histological complete response for patients with advanced gastric cancer after preoperative chemoradiation therapy with S-1 and low-dose cisplatin.2011

    • Author(s)
      Mayanagi S
    • Organizer
      9th International Gastric Cancer Congress
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2011-04-21
  • [Presentation] Laparoscopy-assisted proximal gastrectomy based on the SN concept and esophagogastric anastomosis using the orvil.2011

    • Author(s)
      Takeuchi H.
    • Organizer
      9th International Gastric Cancer Congress
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2011-04-21
  • [Presentation] The role of CD44 variant in the development of spasmolytic polypeptiede expressing metaplasia (SPEM) and gastric cancer.2011

    • Author(s)
      Wada T.
    • Organizer
      AACR 102nd Annual Meeting
    • Place of Presentation
      Florida, USA
    • Year and Date
      2011-04-03
  • [Presentation] Oncologic Outcomes of Laparoscopic Surgery for Gastrointestinal Stromal Tumor (GIST) of the Stomach2011

    • Author(s)
      Wada N
    • Organizer
      SAGES
    • Place of Presentation
      San Antonio, USA
    • Year and Date
      2011-03-31
  • [Presentation] Validation study of sentinel lymph node mapping using radio- and dye-guided methods in gastric cancer: 431 cases at a single institution2011

    • Author(s)
      Niihara M
    • Organizer
      8th Gastrointestinal Cancers Symposium
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2011-01-20
  • [Presentation] Availability of sentinel node as predictive index of lymph node metastases to early-stage gastric cancer surgery.2011

    • Author(s)
      Kamiya S
    • Organizer
      8th Gastrointestinal Cancers Symposium
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2011-01-20
  • [Presentation] The Microanatomic Location of Metastatic Gastric Cancer in Sentinel Lymph Nodes2010

    • Author(s)
      Niihara M
    • Organizer
      The 7th International Sentinel Node Society Meeting
    • Place of Presentation
      Yokohama
    • Year and Date
      2010-11-18
  • [Presentation] Validation Study of Sentinel Lymph Node Mapping Using Radio-and Dye-guided Method in Gastric Cancer2010

    • Author(s)
      Niihara M.
    • Organizer
      The 7th International Sentinel Node Society Meeting
    • Place of Presentation
      Yokohama
    • Year and Date
      2010-11-18
  • [Presentation] Evaluation of the Proximal Gastrectomy with Sentinel Node Biopsy in Gastric Cancer.2010

    • Author(s)
      Kamiya S
    • Organizer
      The 7th International Sentinel Node Society Meeting
    • Place of Presentation
      Yokohama
    • Year and Date
      2010-11-18
  • [Presentation] Evaluation of the Pylorus-preserving Gastrectomy with Sentinel Node Biopsy during an Operation for Less Invasive Surgery2010

    • Author(s)
      Kamiya S.
    • Organizer
      The 7th International Sentinel Node Society Meeting
    • Place of Presentation
      Yokohama
    • Year and Date
      2010-11-18
  • [Presentation] Laparoscopic gastrojejunostomy for malignant gastric outlet obstruction2010

    • Author(s)
      Wada N
    • Organizer
      12th World Congress of Endoscopic Surgery
    • Place of Presentation
      National Harbor, USA
    • Year and Date
      2010-04-16
  • [Book] 今日の治療指針 2012 年版2012

    • Author(s)
      和田則仁、古川俊治
    • Total Pages
      1759-1763
    • Publisher
      医学書院
  • [Book] 症候群ハンドブック2011

    • Author(s)
      和田則仁
    • Total Pages
      255
    • Publisher
      中山書店
  • [Book] 消化器単孔式腹腔鏡下手術2010

    • Author(s)
      田邉稔, 河地茂行, 板野理, 篠田昌宏, 和田則仁, 大島剛, 小野嘉大, 谷紀幸, 上田政和, 北川雄光
    • Total Pages
      79-91
    • Publisher
      南山堂
  • [Remarks]

    • URL

      http://plaza.umin.ac.jp/~nori/hp/research.htm

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Published: 2014-08-29  

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