Investigation of the mechanisms of pouchitis after IPAA for patients with ulcerative colitis.

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591476
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Tohoku University
• Principal Investigator: OGAWA Hitoshi 東北大学, 病院, 講師 (00312570)
• Co-Investigator(Kenkyū-buntansha): SHIBATA Chikashi 東北大学, 大学院・医学系研究科, 准教授 (30270804) ; SASAKI Iwao 東北大学, 大学院・医学系研究科, 教授 (60125557)
• Project Period (FY): 2010 – 2012
• Keywords: 潰瘍性大腸炎 / 回腸嚢炎

Research Abstract

In the clinical study, we evaluated the long-term outcome of pouchitis following total proctocolectomy and IPAA for patients with ulcerative colitis. In the basic study, we revealed the effect of IL-23 in the intestinal neuroendocrine and cancer cells.

Research Products

• [Journal Article] Adenocarcinoma associated with perianal fistulas in Crohn's disease (2013)
  • Author(s): Ogawa H, Haneda S, Shibata C, Miura K, Nagao M, Ohnuma S, Kohyama A, Unno M.
  • Journal Title: Anticancer Res Volume: 33(2) Pages: 685-9
• [Journal Article] A shift from colon- to ileum-predominant bacteria in ileal-pouch feces following total proctocolectomy (2012)
  • Author(s): Hinata M, Kohyama A, Ogawa H, Haneda S, Watanabe K, Suzuki H, Shibata C, Funayama Y, Takahashi K, Sasaki I, Fukushima K.
  • Journal Title: Dig Dis Sci Volume: 57(11) Pages: 2965-74
  • DOI: doi:10.1007/s10620-012-2165-9.
• [Journal Article] A unique variant of afferent limb syndrome after ileal pouch-anal anastomosis: a case series and review of the literature (2012)
  • Author(s): Ogawa H, Haneda S, Watanabe K, Suzuki H, Miura K, Ohnuma S, Sasaki H, Shibata C, Unno M
  • Journal Title: J Gastrointest Surg Volume: 16(8) Pages: 1581-4
  • DOI: doi:10.1007/s11605-012-1872-z.
• [Journal Article] IL-23 directly enhances the proliferative and invasive activities of colorectal carcinoma (2012)
  • Author(s): Suzuki H, Ogawa H, Miura K, Haneda S, Watanabe K, Ohnuma S, Sasaki H, Sase T, Kimura S, Kajiwara T, Komura T, Toshima M, Matsuda Y, Shibata C, Sasaki I
  • Journal Title: Oncol Lett Volume: 4(2) Pages: 199-204
• [Journal Article] The long-term clinical course of pouchitis after total proctocolectomy and IPAA for ulcerative colitis (2012)
  • Author(s): Suzuki H, Ogawa H, Shibata C, Haneda S, Watanabe K, Takahashi K, Funayama Y, Sasaki I.
  • Journal Title: Dis Colon Rectum Volume: 55(3) Pages: 330-6
  • DOI: doi:10.1097/DCR.0b013e3182417358.
• [Presentation] 大腸全摘・回腸嚢肛門吻合術後Afferent Loop Syndromeの検討 (2012)
  • Author(s): 小川仁、柴田近、三浦康、佐々木宏之、羽根田祥、渡辺和宏、鈴木秀幸、海野倫明
  • Organizer: 第67回日本消化器外科学会総会
  • Place of Presentation: 富山
  • Year and Date: 2012-07-19
• [Presentation] IL-23 Regulates Gene Expressions via STAT3 Activation in the Human Intestinal Neuroendocrine Cell Line (2012)
  • Author(s): Suzuki H, Ogawa H, Miura K, Naitoh T, Shibata C
  • Organizer: DDW2012
  • Place of Presentation: アメリカ合衆国(San Diego)
  • Year and Date: 2012-05-22
• [Presentation] IL-23はSTAT3を介して腸管の神経内分泌細胞に作用する (2012)
  • Author(s): 鈴木秀幸、小川仁,三浦康,内藤剛,羽根田祥,渡辺和宏,大沼忍,佐々木宏之,鹿郷昌之,田中直樹,工藤克昌,佐瀬友彦,木村俊一,梶原大輝,小村俊博,戸嶋政秀,松田泰史,柴田近,佐々木巌
  • Organizer: 第98回日本消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-21
• [Presentation] IL-23は直接的に大腸癌の増殖能・浸潤能を亢進させる (2012)
  • Author(s): 鈴木秀幸、小川仁,三浦康,羽根田祥,渡辺和宏,大沼忍,佐々木宏之,佐瀬友彦,木村俊一,梶原大輝,小村俊博,戸嶋政秀,松田泰史,柴田近,佐々木巖
  • Organizer: 第112回日本外科学会定期学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2012-04-14