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2012 Fiscal Year Final Research Report

The mechanism and overcome of resistance to anti-VEGF antibody, bevacizumab in colon cancer

Research Project

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Project/Area Number 22591478
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionInternational University of Health and Welfare

Principal Investigator

TAKAHASHI Yutaka  国際医療福祉大学, 臨床医学研究センター, 教授 (10179541)

Co-Investigator(Kenkyū-buntansha) KITADAI Yashuhiko  広島大学, 大学院・医歯薬総合研究科, 准教授 (10304437)
Project Period (FY) 2010 – 2012
Keywords大腸癌外科学
Research Abstract

We studied the mechanism and overcome of resistance to anti-VEGF antibody , bevacizumab. We could not find any upregulated genes in transplanted tumors and clinical tumors which were resistant to bevacizumab while bevacizumab therapies by several microarray studies. These results suggest that the resistance to anti-VEGF would be rare rather than conventional cancer drugs and other molecular targeting drugs.

  • Research Products

    (2 results)

All 2011

All Journal Article (2 results)

  • [Journal Article] Therapeutic approaches targeting tumor vaslature in gastrointestinal cancers2011

    • Author(s)
      Takahashi Y and Nishioka K
    • Journal Title

      Front Biosci

      Volume: 3 Pages: 541-548

  • [Journal Article] Randomized phase II trial of first-line treatment with tailored irinotecan and S-1 therapy versus S-1 monotherapy for advanced or recurrent gastric carcinoma (JFMC31-0301)2011

    • Author(s)
      Komatsu Y, Takahashi Y, Kimura Y, Oda H, Tajima Y, Tamura S, Sakurai J, Wakasugi T, Tatebe S, Takahashi M, Sakata Y, Kitajima M, Sakamoto J, Saji S
    • Journal Title

      Anticancer Drugs

      Volume: 22(6) Pages: 576-83

URL: 

Published: 2014-08-29  

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