2012 Fiscal Year Final Research Report
Cloning of a splicing variant of EG-VEGF in colorectal cancer.
| Project/Area Number |
22591481
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | University of Fukui |
|---|
Principal Investigator |
GOI Takanori 福井大学, 医学部附属病院, 講師 (60225638)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YAMAGICHI Akio 福井大学, 医学部, 教授 (10174608)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 大腸癌 / 血管新生因子 / 浸潤 / 転移 |
|---|
| Research Abstract |
We identified a novel EG-VEGF gene with a splicing pattern different from that of the regular EG-VEGF gene. Comparison of both genes revealed that the variantEG-VEGF products had a structure lacking thirty-six base pair. Variant EG-VEGF protein increased cancer cell invasion. In addition, Variant EG-VEGF mRNA was found to be expressed in liver metastatic lesion , suggesting that it is an important gene for the function of hematogenous metastasis.
|
Research Products
(10 results)
