2012 Fiscal Year Final Research Report

Influence of mesenchymal stem cells on intestinal tissue engineering combined with Bianchi's procedure using small intestinal submucosa

Research Project

Project/Area Number	22591488
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Digestive surgery
Research Institution	Yamaguchi University
Principal Investigator	UENO Tomio 山口大学, 医学部附属病院, 講師 (70284255)
Project Period (FY)	2010 – 2012
Keywords	消化管再生医療 / 小腸粘膜下組織 / 間葉系幹細胞 / 小腸伸長術
Research Abstract	Small intestinal submucosa (SIS) is a biodegradable collagen-rich matrix containing functional growth factors. In this study, we investigated the feasibility of SIS in conjunction with mesenchymal stem cells (MSCs) for regeneration of the gastrointestinal tract. Also, we examined the achievability of SIS as a bioscaffold when combined with small intestinal tissue engineering and Bianchi’s procedure. Seeded MSCs provided an enriched environment that supported tissue regeneration by the SIS graft in the engineered stomach. SIS has the potential for use as a scaffold that promotes the formation of a physical and physiological neointestine, which means that our proposal approaches a novel surgical treatment even in patients with short bowel syndrome.

(4 results)