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2012 Fiscal Year Final Research Report

Enteric neural regeneration and neurogenesis by mosapride

Research Project

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Project/Area Number 22591491
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionNara Medical University

Principal Investigator

FUJII Hisao  奈良県立医科大学, 医学部, 准教授 (40156823)

Co-Investigator(Kenkyū-buntansha) TAKAKI Miyako  奈良県立医科大学, 医学部, 特任教授 (00033358)
Research Collaborator KAWAHARA Isao  奈良県立医科大学, 大学院・医学研究科, 院生
GOTO Kei  奈良県立医科大学, 大学院・医学研究科, 院生
MISAWA Hiromi  奈良県立医科大学, 医学部, 教務職員
Project Period (FY) 2010 – 2012
Keywords小腸大腸肛門外科学
Research Abstract

In rat models those underwent rectal transection and anastomosis simulating rectal cancer surgery, effects of a 5-HT_4 receptor agonist, mosapride citrate on enteric neural regeneration and neurogenesis were investigated. Two weeks after administration of mosapride, enteric nerves dissected by the surgery were regenerated and connected at the anastomosis and enteric new neurons were observed at the granulation tissue formed during the injury-curing processes. A 5-HT_4 receptor blocker antagonized these effects, indicating that the effect of mosapride is mediated via 5-HT_4 receptor

  • Research Products

    (11 results)

All 2013 2012 2011 2010

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (8 results)

  • [Journal Article] The comparison of effects of a selective 5-HT reuptake inhibitor versus a 5-HT4 receptor agonist on in vivo neurogenesis at the recta anastomosis in rats2012

    • Author(s)
      Kawahara I, Kuniyasu H, Matsuyoshi H, Goto K, Obata K, Misawa H, Fujii H, Takaki M
    • Journal Title

      American Journal Physiology Gastrointestinal Physiology

      Volume: 302 Pages: G588-G597

    • Peer Reviewed
  • [Journal Article] In vitro enhanced differ- rentiation of neural networks in ES gut-like organ from mouse ES cells by a 5-HT_4-receptor activation2011

    • Author(s)
      Takaki M, Misawa H, Matsuyoshi H, Kawahara I, Goto K, Zhang GX, Obata K, Kuniyasu H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 406 Pages: 529-533

    • Peer Reviewed
  • [Journal Article] 排便機能障害とその治療の新しい可能性2010

    • Author(s)
      高木 都、松吉ひろ子、 國安弘基、 勝井錬太
    • Journal Title

      日本病態生理学会雑誌

      Volume: 19(2) Pages: 20-27

  • [Presentation] 2MS4B-5 下部消化管の生理機能-排便反射機構の神経性調節2013

    • Author(s)
      高木 都
    • Organizer
      第90回日本生理学会大会入澤宏・彩記念 JPS優秀論文賞(入澤賞)シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2013-03-28
  • [Presentation] In vivo neural regeneration and neurogenesis promoted by 5-HT_4 receptor activation2012

    • Author(s)
      Takaki M, Kuniyasu H, Kawahara I, Goto K, Matsuyoshi H
    • Organizer
      Neuro- gastroenterology and Motility 2012 Joint International Meeting
    • Place of Presentation
      Bologna, Italy
    • Year and Date
      20120906-08
  • [Presentation] 選択的セロトニン再取り込み阻害薬とセロトニン受容体作動薬が腸壁内神経損傷後のin vivo神経再建に与える効果の比較2012

    • Author(s)
      川原 勲、國安弘基、後藤 桂、小畑孝二、 藤井久男、 高木 都
    • Organizer
      第5回J-FD研究会
    • Place of Presentation
      東京
    • Year and Date
      2012-11-10
  • [Presentation] 5-HT4 受容体作動薬モサプリドによるマウス回腸切離吻合術後の腸壁内神経再生・新生促進作用の2光子顕微鏡による in vivoイメージング法での解析2011

    • Author(s)
      後藤 桂、加藤 剛、國安弘基、松吉ひろ子、川原 勲、藤井久男、鍋倉淳一、高木 都
    • Organizer
      第53回日本平滑筋学会総会
    • Place of Presentation
      ゆうぽうと東京
    • Year and Date
      20110803-04
  • [Presentation] 選択的セロトニン再取り込み阻害薬、フルボキサミンマレイン酸塩の腸壁内神経損傷後の in vivo再建に対する効果2011

    • Author(s)
      川原 勲、 松吉ひろ子、國安弘基、 後藤 桂、小畑孝二、藤井久男、高木 都
    • Organizer
      第53回日本平滑筋学会総会
    • Place of Presentation
      ゆうぽうと東京
    • Year and Date
      20110803-04
  • [Presentation] 選択的セロトニン再取り込み阻害薬、フルボキサミンマレイン酸塩の腸壁内神経損傷後の in vivo 再建に対する効果2011

    • Author(s)
      川原 勲、松吉ひろ子、國安弘基、後藤桂、小畑幸司、藤井久男、高木 都
    • Organizer
      第104回近畿生理学談話会
    • Place of Presentation
      大阪医科大学
    • Year and Date
      2011-10-01
  • [Presentation] Pathophysiological pathways in gastrointestinal disease: gastro- intestinal motility disorders2010

    • Author(s)
      Takaki M, Matsuyoshi H, Misawa H, Katsui R, Fujii H, Kuniyasu H
    • Organizer
      The 6th International Congress of Patho- physiology "Gene-environment inter- action in health and disease. (Symposium 1 Pathophysiological pathways: Gastrointestinal and lung diseases. Keynote speaker)
    • Place of Presentation
      Montreal Convention Centre, Canada
    • Year and Date
      20100922-25
  • [Presentation] The role of ENS and ICC in Gastrointestinal motility disorders2010

    • Author(s)
      Takaki M, Matsuyoshi H, Kuniyasu H, Misawa H, Katsui R, Fujii H, Zhang G-X, Obata K, Takeshita D
    • Organizer
      Invited Neuroscience Seminar at Vermont University
    • Place of Presentation
      Burlington in Vermont
    • Year and Date
      2010-09-24

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Published: 2014-08-29  

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