2012 Fiscal Year Final Research Report
A new perspective for extending use of steatotic liver graft by analyzing for phosphorylation signaling pathway and applying for endothelial progenitor cells.
| Project/Area Number |
22591500
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MIYAZAKI Masaru 千葉大学, 大学院・医学研究院, 教授 (70166156)
KIMURA Fumio 千葉大学, 大学院・医学研究院, 特任教授 (70334208)
TAKEUCHI Dan 千葉大学, 医学部附属病院, 助教 (20400822)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 脂肪肝 / 生体部分肝移植 / 肝再生 / リン酸化シグナル |
|---|
| Research Abstract |
The steatotic liver is vulnerable to hepatic ischemia/reperfusion, leading to significant hepatocyte apoptosis by the mitochondrial permeability transition, and thereby resulting in organ dysfunction. In addition, regeneration of the steatotic liver after extended hepatectomy is impaired by a decrease in ATP levels and a decrease in activation of phosphorylation of survival signal.
|
Research Products
(7 results)
