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2012 Fiscal Year Final Research Report

Mechanism of anti-infectious property of heart-valve and vascular homograftmanipulation

Research Project

  • PDF
Project/Area Number 22591537
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionThe University of Tokyo

Principal Investigator

SAITO Aya  東京大学, 医学部附属病院, 助教 (10431868)

Co-Investigator(Kenkyū-buntansha) MOTOMURA Noboru  東京大学, 医学部附属病院, 講師 (40332580)
Co-Investigator(Renkei-kenkyūsha) NOGUCHI Norihisa  東京薬科大学, 薬学部, 準教授
KAKIMI Kazuhiro  東京大学, 医学部附属病院, 特任準教授
Project Period (FY) 2010 – 2012
Keywords心臓血管外科学 / MRSA
Research Abstract

Recent experiments with fresh vascular allografts showed suppression of MRSA growth by the induction of immune response and tryptophan metabolism via the IDO pathway. In this study, the impact of cryopreservation on a potential key role in the anti-MRSA resistance was analyzed. Brown Norway and Lewis rats were used for allogeneic transplantation models, and fresh allograft (FA) and cryopreserved allograft (CA) were used as conduits. The grafts were recovered on postoperative day 7 and 14 and submitted for real-time PCR andMRSA proliferation assay. IFNγ, TNFα and IDO gene expression in FA was higher than inCA on days 7 and 14, and both FA and CA groups showed significant suppression of MRSA growth compare to control group. In conclusion, both FA and CA suppressed MRSA proliferation. IDO expression in CA was lower than in FA, but sufficient to suppress MRSA growth was expected.

  • Research Products

    (13 results)

All 2012 2011 2010

All Journal Article (6 results) Presentation (7 results)

  • [Journal Article] Outcome of surgical repair of aorto-eosophageal fistulas with cryopreserved aortic allografts.2012

    • Author(s)
      Saito, A., Motomura, N., Hattori, O.,Kinoshita, O., Shimada, S., Saiki, Y., Kyo, S. and Ono, M.
    • Journal Title

      Interact CardiovascThorac Surg

      Volume: 14 Pages: 532-537

  • [Journal Article] 心臓手術の実際-ホモグラ フトを用いた大動脈基部置換 術2012

    • Author(s)
      齋藤 綾
    • Journal Title

      Clinical Engineering

      Volume: Vol 23(3) Pages: 250-253

  • [Journal Article] 同種心臓弁・血管2011

    • Author(s)
      齋藤 綾、小野 稔
    • Journal Title

      臨床と研究

      Volume: Vol88 Pages: 410-414

  • [Journal Article] Outcomes of midterm circulatory support by left ventricular assist device implantation with descending aortic anastomosis.2010

    • Author(s)
      Nawata, K., Nishimura, T., Kyo, S., Hisagi, M., Kinoshita, O., Saito, A., Motomura, N., Takamoto, S. and Ono, M.
    • Journal Title

      J Artif Organs

      Volume: 13 Pages: 197-201

  • [Journal Article] Regulatory T cells are critical to tolerance induction in presensitized mouse transplant recipients through targeting memory T cells.2010

    • Author(s)
      Ge, W., Jiang, J., Liu, W., Lian, D., Saito, A., Garcia, B., Li, X. C. and Wang, H.
    • Journal Title

      Am J Transplant

      Volume: 10 Pages: 1760-1773

  • [Journal Article] Thrombotic occlusion of the ascending aorta afterToyobo LVADimplantation with descending aortic perfusion in a post-Bentall patient.2010

    • Author(s)
      Nawata, K., Nishimura, T., Kyo, S., Hisagi, M., Kinoshita, O., Saito, A., Motomura, N., Takamoto, S. and Ono, M.
    • Journal Title

      J Artif Organs

      Volume: 13 Pages: 228-231

  • [Presentation] Surgical Strategy for Aortoesophageal Fistula - Effective use of EndovascularStentgrafts and Cryopreserved Aortic Allografts.2012

    • Author(s)
      Saito A., Motomura N., et.al.
    • Organizer
      第76回日本循環器学会総会
    • Place of Presentation
      福岡.
    • Year and Date
      20120000
  • [Presentation] Aortic root replacement with cryopreserved aortic valve allograft 12-year experience from University of Tokyo Tissue Bank2011

    • Author(s)
      Saito A., Motomura N., et.al.
    • Organizer
      16th ISC annual meeting. Vienna
    • Place of Presentation
      Austria
    • Year and Date
      20110000
  • [Presentation] Aortic root replacement in critical infective endocarditis with cryopreserved heart valve allograft effective use of arterial allografts for coronary artery reconstruction2011

    • Author(s)
      Saito A., Motomura N., et.al.
    • Organizer
      19th ASCVTS annual meeting
    • Place of Presentation
      PuhketThailand.
    • Year and Date
      20110000
  • [Presentation] Surgical outcome of cryopreserved aortic allografts for aortoesophageal fistula.2011

    • Author(s)
      Saito A., Motomura N., et.al.
    • Organizer
      26th EACTS annual meeting
    • Place of Presentation
      Lisbon, Portugal.
    • Year and Date
      20110000
  • [Presentation] 凍結保存同種 血管・心臓弁組織移植-先進医療と保険 診療の間で-2011

    • Author(s)
      齋藤 綾、本村 昇、他。
    • Organizer
      第75回日本循環器学会総会
    • Place of Presentation
      横浜
    • Year and Date
      20110000
  • [Presentation] Cryopreserved arterial allograft for coronary artery reconstruction in critical infective endocarditis cases2010

    • Author(s)
      Saito A, Motomura N., et.al.
    • Organizer
      Cryopreserved arterial allograft for coronary artery reconstruction in critical infective endocarditis cases CRYO2010 Bristol
    • Place of Presentation
      UK
    • Year and Date
      20100000
  • [Presentation] 凍結保存心臓弁・血管組織の臨床応用-東京大学組織バンクの活動状況より2010

    • Author(s)
      齋藤 綾、本村 昇 他。
    • Organizer
      第110回日本外科学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      20100000

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Published: 2014-08-29   Modified: 2015-05-25  

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