Age-related rupture of internal elastic lamina in atherosclerosis: ultrastrucutral analysis of its occurrence and healing.

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591542
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Okayama University
• Principal Investigator: OHTSUKA Aiji 岡山大学, 大学院・医歯薬学総合研究科, 教授 (50168986)
• Co-Investigator(Kenkyū-buntansha): TAGUCHI Takehito 岡山大学, 大学院・保健学研究科, 教授 (70188134) ; MOMOTA Ryusuke 岡山大学, 大学院・医歯薬学総合研究科, 助教 (80263557)
• Project Period (FY): 2010 – 2012
• Keywords: 弾性線維 / 動脈硬化症 / 内弾性板 / 走査型電子顕微鏡 / 血管鋳型法 / 消化法

Research Abstract

At first, we newly developed scanning electron microscopy technique using a formic acid digestion with vascular casts, which revealed, in detail, the three-dimensional(3D) architecture of delicate elastic fibers in small vessels. This method could successfully visualized the three-dimensional architecture of elastic fibers in small various sized of blood vessels, even arterioles and venules. Furthermore, the new method revealed the 3D architectures of corrupted internal elastic lamina.

Research Products

• [Journal Article] Architecture of the subendothelial elastic fibers of small blood vessels and variations in vascular type and size (2013)
  • Author(s): Shinaoka A, Momota RKosaka M, Kumagishi K, Nakahara R, Naito I, Ohtsuka A
  • Journal Title: Microscopy and Microanalysis Volume: 19(2) Pages: 406-414
  • Peer Reviewed
• [Presentation] 微小血管の内皮下弾性線維の走査電子顕微鏡観察～血管の種類とサイズに応じての変化 (2012)
  • Author(s): 品岡 玲、百田龍輔、熊岸加苗、小阪美津子、中原龍一、内藤一郎、大塚愛二
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨
  • Year and Date: 2012-03-27
• [Presentation] 微小血管内皮下弾性線維構造と血行動態の関係 (2011)
  • Author(s): 品岡 玲、百田龍輔 、小阪美津子、内藤一郎、中原龍一、大塚愛二
  • Organizer: 第43回日本結合組織学会・第58回マトリックス研究会合同学術集会
  • Place of Presentation: 大分
  • Year and Date: 2011-06-11
• [Remarks]
  • URL: http://www.okayama-u.ac.jp/user/anatomy/hm/index.html