2012 Fiscal Year Final Research Report
MicroRNAs Analysis for Investigation of the Causes in Human Atrium Electrical Remodeling
| Project/Area Number |
22591547
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Oita University |
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Principal Investigator |
IWATA Eriko 大分大学, 医学部, 医員 (70457604)
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| Co-Investigator(Kenkyū-buntansha) |
ONO Katishige 大分大学, 医学部病態生理学講座, 教授 (40253778)
MORISHIMA Masaki 大分大学, 医学部病態生理学講座, 助教 (40437934)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 循環器 / 不性脈 / イオンチャネル / マイクロ RNA / 心房細動 / 体外循環 |
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| Research Abstract |
Even though atrial fibrillation is the most commonly encountered clinical arrhythmia,the therapeutic strategy has not been established. Atrial tissue was obtained from patients undergoing cardiovascular surgery using extracorporial circulation. W e identified some ion channels and microRNAs that were down-regulated or up-regulated in atrial fibrillation patients, and suggested it’ s relation to ion channel remodeling and the possibility of therapeutic application.
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