2012 Fiscal Year Final Research Report
Sonic Hedgehog Promotes Vasculogenic Activity in humanCD34 positive Cells
| Project/Area Number |
22591555
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Kurume University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
II Masaki 大阪医科大学, 医学部, 講師 (10442922)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 心臓大血管外科学 |
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| Research Abstract |
The activation of SHh signaling by SHh treatment of human CD34+cells enhanced the migration, proliferation, adhesion, and colony forming capacities thatare essential for neovascularization including vasculogenesis/arteriogenesis. We havedemonstrated the differentiation potential of CD34+ cells into both endothelial cells andvascular smooth muscle cells exhibiting up-regulation of genes expressed in vascularlineage cells. The SHh activated human CD34+ cells directly contributed to vascularregeneration while non-activated CD34+ cells showed less regenerative capacity in a mouseischemic hindlimb model. The activation of cellular SHh signaling may increase thepotency of autologous CD34+ cell therapy in ischemic diseases.
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