2012 Fiscal Year Final Research Report
Elucidation of the mechanism of transplanted rejected airways with special reference to epithelial to mesenchymal transition
| Project/Area Number |
22591560
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAJIMA Jun 東京大学, 医学部附属病院, 教授 (90188954)
SANO Atsushi 東京大学, 医学部附属病院, 助教 (20569834)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 呼吸器外科学 / 移植 / 線維化 / 閉塞性細気管支炎 |
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| Research Abstract |
We confirmed that epithelial to mesenchymal transition had some roles in transplanted rejected airways using histological assessment of changes over time. On the other hand, our results using transgenic mice revealed that the fibroblasts in fibrosis of transplanted airways originated from the recipient. This suggests that blocking fibroblasts differentiation from recipient bone marrow precursor cells may lead to preventing fibrosis in transplanted organs.
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[Journal Article] CpG island methylation of microRNAs is associated with tumor size and recurrence of non-small-cell lung cancer.2011
Author(s)
Kentaro Kitano, Kousuke Watanabe,Noriko Emoto, Hidenori Kage, Emi Hamano, Takahide Nagase, Atsushi Sano, Tomohiro Murakawa, Jun Nakajima, Akiteru Goto, Masashi Fukayama, Yutaka Yatomi, Nobuya Ohishi, Daiya Takai.
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Journal Title
Cancer Science
Volume: 102(12)2126-31
Pages: 1349-7006
DOI
Peer Reviewed
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