2012 Fiscal Year Final Research Report
Significant role of bone marrow-derived cells in compensatory regenerative lung growth
| Project/Area Number |
22591569
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Yamaguchi University |
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Principal Investigator |
UEDA Kazuhiro 山口大学, 医学部附属病院, 講師 (90420520)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Toshiki 山口大学, 医学部附属病院, 助教 (50457305)
LI Taosheng 長崎大学, 大学院・医歯薬学総合研究科, 教授 (50379997)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 骨髄由来細胞 / 代償性肺成長 |
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| Research Abstract |
Regenerative lung growth was induced by left pneumonectomy in GFP-positive bone marrow-transplanted chimeric mice. GFP-positive cells were observed 2.1-fold more frequently in the lungs of pneumonectomized mice vs. sham operated mice by immunohistochemistry (P=0.001). Pneumonectomy induced a 1.4-fold increase in the SDF-1α level in the remaining lung at seven days compared to sham operated mice (P
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