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2012 Fiscal Year Final Research Report

Elucidation of pathogenesis and new treatment for brain injury after subarachnoid hemorrhage

Research Project

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Project/Area Number 22591584
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionMie University

Principal Investigator

SUZUKI Hidenori  三重大学, 大学院・医学系研究科, 教授 (90345976)

Project Period (FY) 2010 – 2012
Keywords脳血管障害学 / くも膜下出血 / 脳損傷 / 細胞外基質蛋白
Research Abstract

Subarachnoid hemorrhage (SAH)-induced early brain injury (EBI) potentially contributes to poor outcome, one of whose key pathologic manifestation is the breakdown of the blood-brain barrier (BBB). We determined the role of osteopontin (OPN), a pleiotropic extracellular matrix glycoprotein (matricellular protein [MCP]), in the post-SAH BBB disruption in rats. The OPN levels in the brain were significantly induced and peaked at 72 hours after SAH, in the recovery phase of EBI. OPN siRNA significantly blocked the endogenous OPN induction and aggravated neurological impairment and BBB disruption at 72 hours after SAH. Pre-SAH administration of recombinant OPN (r-OPN)significantly prevented a loss in body weight, neurological impairment, brain edema and BBB disruption compared with the control rats. Treatment with r-OPN was associated with the deactivation of NF-κB activity, inhibition of MMP-9 induction, and the consequent preservation of cerebral microvessel basal lamina proteins and tight junction proteins.These findings suggest the protective effects of OPN against BBB disruption after SAH.In addition, we obtained new findings, suggesting that tenascin-C, another MCP, causes brain injury after SAH.

  • Research Products

    (34 results)

All 2013 2012 2011 2010

All Journal Article (15 results) (of which Peer Reviewed: 14 results) Presentation (15 results) Book (4 results)

  • [Journal Article] Imatinib mesylate prevents cerebral vasospasm after subarachnoid hemorrhage via inhibiting tenascin-C expression in rats2012

    • Author(s)
      Masato Shiba, Hidenori Suzuki
    • Journal Title

      Neurobiol Dis

      Volume: 46 Pages: 172-179

    • Peer Reviewed
  • [Journal Article] Treatment with sodium orthovanadate reduces blood-brain barrier disruption via phosphatase and tensin homolog deleted on chromosome 10 (PTEN) phosphorylation in experimental subarachnoid hemorrhage2012

    • Author(s)
      Yu Hasegawa, Hidenori Suzuki
    • Journal Title

      Treatment with sodium orthovanadate reduces blood-brain barrier disruption via phosphatase and tensin homolog deleted on chromosome 10 (PTEN) phosphorylation in experimental subarachnoid hemorrhage

      Volume: 90 Pages: 691-697

    • Peer Reviewed
  • [Journal Article] Isoflurane attenuates blood-brain barrier disruption in ipsilateral hemisphere after subarachnoid hemorrhage in mice2012

    • Author(s)
      Orhan Altay, Hidenori Suzuki
    • Journal Title

      Stroke

      Volume: 43 Pages: 2513-2516

    • Peer Reviewed
  • [Journal Article] Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats2012

    • Author(s)
      Yan Zhan, Chunhua Chen, Hidenori Suzuki, et al
    • Journal Title

      Crit Care Med

      Volume: 40 Pages: 1291-1296

    • Peer Reviewed
  • [Journal Article] アルファ7ニコチン性受容体作動薬PNU-282987のくも膜下出血後early brain injury抑制効果2012

    • Author(s)
      鈴木秀謙
    • Journal Title

      脳血管攣縮

      Volume: 28 Pages: 13-18

    • Peer Reviewed
  • [Journal Article] テネイシンCとearly brain injuryおよび脳血管攣縮との関連2012

    • Author(s)
      鈴木秀謙
    • Journal Title

      脳血管攣縮

      Volume: 28 Pages: 1-4

    • Peer Reviewed
  • [Journal Article] 脳血管疾患とテネイシンC(総説)2011

    • Author(s)
      鈴木秀謙
    • Journal Title

      呼吸と循環

      Volume: 59 Pages: 1099-1105

  • [Journal Article] William Rolland II, Hidenori Suzuki, et al, PDGFR-α inhibition preserves blood-brain barrier afterintracerebral hemorrhage2011

    • Author(s)
      Qingyi Ma, Bin Huang, Nikan Khatibi
    • Journal Title

      Ann Neurol

      Volume: 70 Pages: 920-931

    • Peer Reviewed
  • [Journal Article] Cerebrospinal fluid tenascin-C in cerebral vasospasm after aneurysmal subarachnoid hemorrhage2011

    • Author(s)
      Hidenori Suzuki
    • Journal Title

      J Neurosurg Anesthesiol

      Volume: 23 Pages: 310-317

    • Peer Reviewed
  • [Journal Article] Preservation of tropomyosin-related kinase B (TrkB) signaling by sodium orthovanadate attenuates early brain injury after subarachnoid hemorrhage in rats2011

    • Author(s)
      Yu Hasegawa, Hidenori Suzuki
    • Journal Title

      Stroke

      Volume: 42 Pages: 477-483

    • Peer Reviewed
  • [Journal Article] Osteopontin reduced hypoxia-ischemia neonatal brain injury by suppression of apoptosis in a rat pup model2011

    • Author(s)
      Wanqiu Chen, Qingyi Ma, Hidenori Suzuki
    • Journal Title

      Stroke

      Volume: 42 Pages: 764-769

    • Peer Reviewed
  • [Journal Article] Tenascin-C is induced in cerebral vasospasm after subarachnoid hemorrhage in rats and humans2010

    • Author(s)
      Hidenori Suzuki
    • Journal Title

      Neurol Res

      Volume: 32 Pages: 179-184

    • Peer Reviewed
  • [Journal Article] Protective effects of recombinant osteopontin on early brain injury after subarachnoid hemorrhage in rats2010

    • Author(s)
      Hidenori Suzuki
    • Journal Title

      Crit Care Med

      Volume: 38 Pages: 612-618

    • Peer Reviewed
  • [Journal Article] Mechanisms of osteopontin-induced stabilization of blood-brain barrier disruption after subarachnoid hemorrhage in rats2010

    • Author(s)
      Hidenori Suzuki
    • Journal Title

      Stroke

      Volume: 41 Pages: 1783-1790

    • Peer Reviewed
  • [Journal Article] Recombinant osteopontin in cerebral vasospasm after subarachnoid hemorrhage2010

    • Author(s)
      Hidenori Suzuki
    • Journal Title

      Ann Neurol

      Volume: 68 Pages: 650-660

    • Peer Reviewed
  • [Presentation] 、 テネイシンCとearly brain injuryおよび脳血管攣縮との関連(シンポジウム)2012

    • Author(s)
      鈴木秀謙
    • Organizer
      第28回スパズムシンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2012-04-26
  • [Presentation] Tenascin-Cは脳動脈を収縮させる(シンポジウム)2012

    • Author(s)
      藤本昌志、鈴木秀謙
    • Organizer
      第28回スパズムシンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2012-04-26
  • [Presentation] ラットくも膜下出血後early brain injuryにおけるテネイシンCの役割(シンポジウム)2012

    • Author(s)
      芝 真人、鈴木秀謙
    • Organizer
      第28回スパズムシンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2012-04-26
  • [Presentation] Tenascin-Cの脳動脈収縮効果2012

    • Author(s)
      藤本昌志、鈴木秀謙
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-26
  • [Presentation] くも膜下出血後脳血管攣縮におけるテネイシンC の役割2011

    • Author(s)
      芝 真人、鈴木秀謙
    • Organizer
      第1回テネイシンフォーラム
    • Place of Presentation
      津
    • Year and Date
      2011-11-05
  • [Presentation] 、くも膜下出血後脳損傷および脳血管攣縮におけるマトリックス細胞蛋白質の役割(特別講演)2011

    • Author(s)
      鈴木秀謙
    • Organizer
      第32回東海クモ膜下出血研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-28
  • [Presentation] くも膜下出血後脳血管攣縮におけるPDGF受容体の役割2011

    • Author(s)
      芝 真人、鈴木秀謙
    • Organizer
      第70回日本脳神経外科学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-10-14
  • [Presentation] Tenascin-Cの脳動脈収縮効果およびその機序についての検討2011

    • Author(s)
      藤本昌志、鈴木秀謙
    • Organizer
      第70回日本脳神経外科学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-10-14
  • [Presentation] ラットくも膜下出血モデルにおける神経学的評価(シンポジウム)2011

    • Author(s)
      鈴木秀謙
    • Organizer
      第27回スパズムシンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2011-07-30
  • [Presentation] ラットくも膜下出血モデルにおけるImatinib の抗脳血管攣縮効果(シンポジウム)2011

    • Author(s)
      芝 真人、鈴木秀謙
    • Organizer
      第27回スパズムシンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2011-07-30
  • [Presentation] Matricellular protein: a new player in cerebral vasospasm following subarachnoid hemorrhage2011

    • Author(s)
      Hidenori Suzuki
    • Organizer
      The 11th International Conference on Neurovascular Events after Subarachnoid Hemorrhage
    • Place of Presentation
      Cincinnati, USA
    • Year and Date
      2011-07-23
  • [Presentation] Role of platelet-derived growth factor in cerebral vasospasm after subarachnoid hemorrhage in rats2011

    • Author(s)
      Masato Shiba, Hidenori Suzuki
    • Organizer
      The 11th International Conference on Neurovascular Events after Subarachnoid Hemorrhage
    • Place of Presentation
      Cincinnati, USA
    • Year and Date
      2011-07-23
  • [Presentation] Hidenori Suzuki osteopontin and tenascin-C in cerebral vasospasm after subarachnoid hemorrhage in rats2011

    • Author(s)
      Hidenori Suzuki
    • Organizer
      第10回オステオポンチン研究会
    • Place of Presentation
      札幌
    • Year and Date
      2011-06-19
  • [Presentation] くも膜下出血後の血液脳関門障害におけるオステオポンチンの役割2010

    • Author(s)
      鈴木秀謙
    • Organizer
      第69回日本脳神経外科学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-29
  • [Presentation] Effects of recombinant osteopontin on blood-brain barrier disruption after subarachnoid hemorrhage in rats2010

    • Author(s)
      Hidenori Suzuki
    • Organizer
      3rd International Conference on Intracerebral Hemorrhage
    • Place of Presentation
      Rancho Mirage, USA
    • Year and Date
      2010-03-09
  • [Book] Matricellular protein: a new player in cerebral vasospasm following subarachnoid hemorrhage2013

    • Author(s)
      Hidenori Suzuki
    • Total Pages
      213-218
    • Publisher
      Springer-Verlag
  • [Book] Neurobehavioral assessments of subarachnoid hemorrhage2012

    • Author(s)
      Hidenori Suzuki
    • Total Pages
      435-440
    • Publisher
      Humana
  • [Book] Role of osteopontin in early brain injury after subarachnoid hemorrhage in rats2011

    • Author(s)
      Hidenori Suzuki
    • Total Pages
      75-79
    • Publisher
      Springer-Verlag
  • [Book] Effects of recombinant osteopontin on blood-brain barrier disruption after subarachnoid hemorrhage in rats2011

    • Author(s)
      Hidenori Suzuki
    • Total Pages
      231-236
    • Publisher
      Springer-Verlag

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Published: 2014-08-29  

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