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2012 Fiscal Year Final Research Report

Role of indoleamine-2,3-dioxygenase in atherosclerotic carotid artery stenosis

Research Project

  • PDF
Project/Area Number 22591592
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionNagasaki University

Principal Investigator

SUYAMA Kazuhiko  長崎大学, 大学院・医歯薬学総合研究科, 客員研究員 (60236057)

Co-Investigator(Kenkyū-buntansha) NAGATA Akifumi  長崎大学, 大学院・医歯薬学総合研究科, 教授 (10198327)
SO Gohei  長崎大学, 大学病院, 医員 (80530427)
BABA Shiro  長崎大学, 大学病院, 医員 (30530430)
SAITO Kuniaki  京都大学, 大学院・医医学系研究科, 教授 (80262765)
Project Period (FY) 2010 – 2012
Keywords脳血管障害学
Research Abstract

We studied clinical implication of indoleamine-2,3-dioxygenese (IDO), a tryptophan metabolite, for plaque instability in patients undergoing endarterectomy for atherosclerotic carotid stenosis. Although radiological examination such as high-resolution MR plaque imaging could detect plaque instability, any of serological markers has not yet been established. Relevance of local existence of IDO and characteristics of carotid plaque is immuno- histochemically under investigation.

  • Research Products

    (9 results)

All 2012 2011 2010

All Journal Article (5 results) Presentation (4 results)

  • [Journal Article] Assessment of carotid plaque stability based on the dynamic enhancement pattern in plaque components with multi-detector CT angiography2012

    • Author(s)
      Horie N, Morikawa M, Ishizaka S, Takeshita T, So G, Hayashi K, Suyama K, Nagata I
    • Journal Title

      Stroke

      Volume: 43(2) Pages: 393-398

  • [Journal Article] "Snake fang"sign without carotid stenosis on Duplex ultrasonography indicates high risk of artery-to-artery embolic stroke2012

    • Author(s)
      Tateishi Y, Tsujino A, Hamabe J, Tasaki O, Morikawa M, Hayashi T, Horie N, Hayashi K, Suyama K, Nagata I
    • Journal Title

      J Neuroimaging Epub ahead of print

  • [Journal Article] 頚動脈血行再建術における術前血小板凝集能測定の有用性2011

    • Author(s)
      諸藤陽一、宗 剛平、日宇 健、川久保潤一、林健太郎、北川直毅、森川 実、陶山一彦、永田 泉
    • Journal Title

      Shinkei Geka

      Volume: 39(5) Pages: 459-463

  • [Journal Article] 頸動脈ステント留置中に回収されたデブリスの同定: 頸動脈内膜剥離術病理標本と対比して2011

    • Author(s)
      林健太郎、堀江信貴、森川 実、宗 剛平、竹下朝規、陶山一彦、永田 泉
    • Journal Title

      JNET

      Volume: 5 Pages: 99-105

  • [Journal Article] 頸部頸動脈狭窄症の外科治療 (CEA)2010

    • Author(s)
      陶山一彦、永田 泉
    • Journal Title

      Brain Nerve

      Volume: 62 Pages: 1301-1313

  • [Presentation] 頸動脈内膜剥離術におけるrSO2 monitoringのpitfall2011

    • Author(s)
      陶山一彦、永田 泉、他
    • Organizer
      第23回日本脳循環代謝学会総会
    • Place of Presentation
      東京
    • Year and Date
      20111100
  • [Presentation] 頸動脈狭窄症に対する外科治療 -画像および抗血栓療法からみたCEA/CASの使い分けと周術期管理-2011

    • Author(s)
      陶山一彦、永田 泉、他
    • Organizer
      第70回日本脳神経外科学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      20111000
  • [Presentation] 3T MRIによる頸動脈プラークイメージング2011

    • Author(s)
      陶山一彦、永田 泉、他
    • Organizer
      第10回日本頚部脳血管治療学会
    • Place of Presentation
      吹田市
    • Year and Date
      20110600
  • [Presentation] 単一施設における頸動脈狭窄症に対するCEA/CASの使い分け2010

    • Author(s)
      陶山一彦、永田 泉、他
    • Organizer
      第39回日本脳卒中の外科学会
    • Place of Presentation
      盛岡市
    • Year and Date
      20100400

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Published: 2014-08-29  

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