2012 Fiscal Year Final Research Report

The role of gangliosides for neuroregeneration in ischemic stroke

Research Project

Project/Area Number	22591593
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Cerebral neurosurgery
Research Institution	Sapporo Medical University
Principal Investigator	MIKAMI Takeshi 札幌医科大学, 医学部, 講師 (30372816)
Project Period (FY)	2010 – 2012
Keywords	脳神経疾患 / 糖脂質 / ガングリオシド / 脳虚血 / 神経再生
Research Abstract	High performance liquid chromatography (HPLC) was performed to detect the difference of glycolipid between the normal and the infarcted brains, however, the sensitivity was not enough to detect the differences. The microarray analysis indidated that the expression of phosphodiesterase 10A (PDE10A) was high in the infarted brain compared to the normal brain. We performed immunohistochemical analysis with anti-PDE10A antibody. The results indicated that the PDE10A is associated with neural regeneration. Thus, we will perform furth er studies forneuroregeneration with these results.