2012 Fiscal Year Final Research Report
Enhancement of BPA uptake using preloading method in boron neutron capture therap
| Project/Area Number |
22591604
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Fumiyo 筑波大学, 医学医療系, 助教 (30261811)
NAKAI Kei 筑波大学, 医学医療系, 講師 (50436284)
MATSUMURA Akira 筑波大学, 医学医療系, 教授 (90241819)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 脳腫瘍学 / 粒子線治療 |
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| Research Abstract |
Intracellular boron accumulation in CHO-K1 cells was particularly increased by co-loading BPA with L-Tyr-O-Et. This increase is caused by activation of a system L amino acid exchanger between BPA and L-Tyr. We expect that this amion acid transport control will be useful for enhancing intracellular boron accumulation.
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Research Products
(15 results)
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[Journal Article] The status of Tsukuba BNCT trial: BPA-based boron neutron capture therapy combined with X-ray irradiation2011
Author(s)
Yamamoto T, Nakai K, Nariai T, Kumada H, Okumura T, Mizumoto M, Tsuboi K, Zaboronok A, Ishikawa E, Aiyama H, Endo K, Takada T, Yoshida F, Shibata Y, Matsumura A
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Journal Title
Appl Radiat Isot
Volume: 69
Pages: 1817-1818
Peer Reviewed
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[Journal Article] A clinical trial protocol for second line treatment of malignant brain tumors with BNCT at University of Tsukuba2011
Author(s)
Aiyama H, Nakai K, Yamamoto T, Nariai T, Kumada H, Ishikawa E, Isobe T, Endo K, Takada T, Yoshida F, Shibata Y, Matsumura A
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Journal Title
Appl Radiat Isot
Volume: 69
Pages: 1819-22
Peer Reviewed
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[Journal Article] Boron neutron capture therapy combined with fractionated photon irradiation for glioblastoma: A recursive partitioning analysis of BNCT patients2011
Author(s)
Nakai K, Yamamoto T, Aiyama H, Takada T, Yoshida F, Kageji T, Kumada H, Isobe T, Endo K, Matsuda M, Tsurubuchi T, Shibata Y, Takano S, Mizumoto M, Tsuboi K, Matsumura A:
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Journal Title
Appl Radiat Isot
Volume: 69
Pages: 1790-2
Peer Reviewed
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[Presentation] The status of Tsukuba BNCT trial: BPA-based boron neutron capture therapy combined with X-ray irradiation2010
Author(s)
Yamamoto T, Nakai K, Nariai T, Kumada H, Okumura T, Miszumoto M, Tuboi K, Zaboronok A, Ishikawa E, Aiyama H, Endo K, Takada T, Yoshida F, Shibata Y, Matsumura A
Organizer
14th International congress on neutron capture therapy
Place of Presentation
Buenos Aires, Argentina
Year and Date
2010-10-28
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[Presentation] Boron neutron capture therapy combined with fractionated photon irradiation for glioblastoma2010
Author(s)
Nakai K, Yamamoto T, Kageji T, Kumada H, Endo K, Matsuda M, Tsurubuchi T, Shibata Y, Takano S, Matsumura A
Organizer
14th International congress on neutron capture therapy
Place of Presentation
Buenos Aires, Argentina
Year and Date
2010-10-28
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