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2012 Fiscal Year Final Research Report

Enhancement of BPA uptake using preloading method in boron neutron capture therap

Research Project

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Project/Area Number 22591604
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionUniversity of Tsukuba

Principal Investigator

YAMAMOTO Tetsuya  筑波大学, 医学医療系, 講師 (30375505)

Co-Investigator(Kenkyū-buntansha) YOSHIDA Fumiyo  筑波大学, 医学医療系, 助教 (30261811)
NAKAI Kei  筑波大学, 医学医療系, 講師 (50436284)
MATSUMURA Akira  筑波大学, 医学医療系, 教授 (90241819)
Project Period (FY) 2010 – 2012
Keywords脳腫瘍学 / 粒子線治療
Research Abstract

Intracellular boron accumulation in CHO-K1 cells was particularly increased by co-loading BPA with L-Tyr-O-Et. This increase is caused by activation of a system L amino acid exchanger between BPA and L-Tyr. We expect that this amion acid transport control will be useful for enhancing intracellular boron accumulation.

  • Research Products

    (15 results)

All 2012 2011 2010 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (7 results) Book (3 results) Remarks (1 results)

  • [Journal Article] The status of Tsukuba BNCT trial: BPA-based boron neutron capture therapy combined with X-ray irradiation2011

    • Author(s)
      Yamamoto T, Nakai K, Nariai T, Kumada H, Okumura T, Mizumoto M, Tsuboi K, Zaboronok A, Ishikawa E, Aiyama H, Endo K, Takada T, Yoshida F, Shibata Y, Matsumura A
    • Journal Title

      Appl Radiat Isot

      Volume: 69 Pages: 1817-1818

    • Peer Reviewed
  • [Journal Article] A clinical trial protocol for second line treatment of malignant brain tumors with BNCT at University of Tsukuba2011

    • Author(s)
      Aiyama H, Nakai K, Yamamoto T, Nariai T, Kumada H, Ishikawa E, Isobe T, Endo K, Takada T, Yoshida F, Shibata Y, Matsumura A
    • Journal Title

      Appl Radiat Isot

      Volume: 69 Pages: 1819-22

    • Peer Reviewed
  • [Journal Article] Boron neutron capture therapy combined with fractionated photon irradiation for glioblastoma: A recursive partitioning analysis of BNCT patients2011

    • Author(s)
      Nakai K, Yamamoto T, Aiyama H, Takada T, Yoshida F, Kageji T, Kumada H, Isobe T, Endo K, Matsuda M, Tsurubuchi T, Shibata Y, Takano S, Mizumoto M, Tsuboi K, Matsumura A:
    • Journal Title

      Appl Radiat Isot

      Volume: 69 Pages: 1790-2

    • Peer Reviewed
  • [Journal Article] Prognostic factors in glioblastoma multiforme patients receiving high-dose particle radiotherapy or conventional radiotherapy2011

    • Author(s)
      Matsuda M, Yamamoto T, Ishikawa E, Nakai K, Zaboronok A, Takano S, Matsumura A
    • Journal Title

      Br J Radiol

      Volume: No 1 Pages: S54-60

    • Peer Reviewed
  • [Presentation] 招待講演シンポジウム「がんの熱中性子捕捉療法(BNCT)‐治療の現状と将来展望」悪性脳腫瘍のBNCT(加速器計画も含む)2012

    • Author(s)
      山本哲哉
    • Organizer
      第127回日本医学放射線学会 北日本地方会
    • Place of Presentation
      仙台
    • Year and Date
      20121116-17
  • [Presentation] Invited lecture. Boron Neutron Capture Therapy for Newly-Diagnosed Glioblastoma2011

    • Author(s)
      Yamamoto T
    • Organizer
      2011 BNCT Workshop on Clinical Applications
    • Place of Presentation
      Taipei(Taiwan)
    • Year and Date
      20111207-11
  • [Presentation] Invited lecture. Boron Neutron Capture Therapy for Glioblastoma: Clinical Trials and Institutional Experience2011

    • Author(s)
      Yamamoto T
    • Organizer
      6th Young Researchers BNCT Meeting
    • Place of Presentation
      Taiwan
    • Year and Date
      2011-12-06
  • [Presentation] The status of Tsukuba BNCT trial: BPA-based boron neutron capture therapy combined with X-ray irradiation2010

    • Author(s)
      Yamamoto T, Nakai K, Nariai T, Kumada H, Okumura T, Miszumoto M, Tuboi K, Zaboronok A, Ishikawa E, Aiyama H, Endo K, Takada T, Yoshida F, Shibata Y, Matsumura A
    • Organizer
      14th International congress on neutron capture therapy
    • Place of Presentation
      Buenos Aires, Argentina
    • Year and Date
      2010-10-28
  • [Presentation] Boron neutron capture therapy combined with fractionated photon irradiation for glioblastoma2010

    • Author(s)
      Nakai K, Yamamoto T, Kageji T, Kumada H, Endo K, Matsuda M, Tsurubuchi T, Shibata Y, Takano S, Matsumura A
    • Organizer
      14th International congress on neutron capture therapy
    • Place of Presentation
      Buenos Aires, Argentina
    • Year and Date
      2010-10-28
  • [Presentation] BNCT and other emerging treatments for malignant glioma2010

    • Author(s)
      Matsumura A, Yamamoto T, Ishikawa E,Nakai K, Endo K, Takano S, Shibata Y
    • Organizer
      14th International congress on neutron capture therapy
    • Place of Presentation
      Buenos Aires, Argentina
    • Year and Date
      2010-10-28
  • [Presentation] ホウ素中性子捕捉療法の現状と課題2010

    • Author(s)
      山本哲哉
    • Organizer
      第8回東京理科大学DDS研究センターシンポジウム
    • Place of Presentation
      東京理科大学(東京)
    • Year and Date
      2010-10-15
  • [Book] Non-operative BNCT for GBM, in Neutron Capture Therapy, (Sauerwein W, Wittig A, Moss R, Nakagawa Y, Eds.)2012

    • Author(s)
      Yamamoto T and Matsumura A
    • Total Pages
      377-88
    • Publisher
      Springer
  • [Book] Tumors of the Central Nervous System, Vol. 2 1st edition., Chapter 25. GLIOBLASTOMA: BORON NEUTRON CAPTURE THERAPY, (Hayat, M.A. Eds.)2011

    • Author(s)
      Yamamoto T, Nakai K, KumadaH
    • Total Pages
      229-240
    • Publisher
      Springer
  • [Book] 特集 岐路に立つホウ素中性子捕捉療法.医師の立場‐脳神経外科医の視点から2011

    • Author(s)
      山本哲哉
    • Total Pages
      19-20
    • Publisher
      エネルギーレビュー
  • [Remarks]

    • URL

      http://www.md.tsukuba.ac.jp/chs/clinical_sciences/te_yamamoto.htm

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Published: 2014-08-29  

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