2012 Fiscal Year Final Research Report
Overcoming resistant to EGFR inhibitor in glioma
Project/Area Number |
22591612
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Cerebral neurosurgery
|
Research Institution | Hiroshima University |
Principal Investigator |
YAMASAKI Fumiyuki 広島大学, 大学院・医歯薬保健学研究院, 助教 (60444692)
|
Co-Investigator(Kenkyū-buntansha) |
KURISU Kaoru 広島大学, 医歯薬保健学研究院, 教授 (70201473)
SUGIYAMA Kazuhiko 広島大学, 病院, 教授 (30243554)
|
Project Period (FY) |
2010 – 2012
|
Keywords | glioma / EGFR / PEA-15 / erlotnib / diffuseion-weighted imaging / gemcitabine / bevacizumab / seudo-response |
Research Abstract |
PEA-15 expression level, that is the downstream molecule of EGFR signal pathway, was inversely associated with WHO grade and may serve as an important prognostic factor for high-grade astrocytomas. High PEA-15 expression level displayed a significantcorrelation with longer overall survival (OS) in high-grade astrocytomas (P = 0.0024). Gemcitabine increased the cytotoxic effect of erlotinib by downregulating p-Akt in EGFR-overexpressing cells with either intrinsic or acquired erlotinib resistance. The study of advanced MR imaging about brain tumors revealed that the MRS detection of lactate is a prognostic factor in patients with diffuse intrinsic pontine glioma. Calculating the ADC value is useful for distinguishing lymphoma from glioblastoma. The lowest degree of overlapping and a better inverse correspondence with tumor cellularity were obtained with ADCMIN at b-4000s/mm2 at 3 T MRI. High b-value DWI reflects cell density more accurately thanregular b-value DWI. Inpatients with recurrent glioma, high b-value diffusion-weighted criteria are useful for the differentiation between pseudo- and true responses to treatment with bevacizumab
|
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Lymphomas and glioblastomas: Differences in the apparent diffusion coefficient evaluated with high b-value diffusion-weighted magnetic resonance imaging at 3T2012
Author(s)
Doskaliyev A, Yamasaki F (Corresponding author), Ohtaki M, Kajiwara Y, Takeshima Y, Watanabe Y, Takayasu T, Amatya VJ, Akiyama Y, Sugiyama K, Kurisu K
-
Journal Title
Eur J Radiol
Volume: 81
Pages: 339-344
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-