2012 Fiscal Year Final Research Report
Development of intraoperative functional mapping using focal brain-cooling device
| Project/Area Number |
22591613
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Yamaguchi University |
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Principal Investigator |
FUJII Masami 山口大学, 医学部附属病院, 准教授 (90181320)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Michiyasu 山口大学, 大学院・医学系研究科, 教授 (80196873)
KAJIWARA Koji 山口大学, 大学院・医学系研究科, 准教授 (90253161)
IDEGUCHI Makoto 山口大学, 医学部附属病院, 助教 (10452640)
NOMURA Sadahiro 山口大学, 医学部附属病院, 講師 (20343296)
MARUTA Yuichi 山口大学, 大学院・医学系研究科, 助教 (30543970)
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| Co-Investigator(Renkei-kenkyūsha) |
KAJIWARA Koji 山口大学, 大学院・医学系研究科, 准教授 (90253161)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 脳冷却 / 脳機能マッピング / ペルチエ素子 / 言語機能 / 運動機能 |
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| Research Abstract |
An electrical cortical stimulation (ECS)is commonly used for functional mapping in awake craniotomy. However, ECS with a high intensity has a chance to induce epileptic seizures. On the other hand, focal brain cooling (FBC) has a strong suppressive effect for seizures and is able to suppress normal brain function．The aim of this study is to develop a new functional-mapping method with a FBC device. We confirmed 7℃-FBC could suppress speech and sensory functions in awake craniotomy. This phenomenon was reversible and permanent neurological deficit was not happened.
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[Journal Article] Focal brain cooling terminates the faster frequency components of epileptic discharges induced by penicillin G in anesthetized rats2012
Author(s)
Kida H, Fujii M, Inoue T, He Y, Maruta Y, Nomura S, Taniguchi K, Ichikawa T, Saito T, Yamakawa T, Suzuki M
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Journal Title
Clin Neurophysiol
Volume: (Clin Neurophysiol)
Peer Reviewed
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[Journal Article] Establishment of a new conditionally immortalized human brain microvascular endothelial cell line retaining an in vivo blood-brain barrier function2010
Author(s)
Sano Y, Shimizu F, Abe M, Maeda T, Kashiwamura Y, Ohtsuki S, Terasaki T, Obinata M, Kajiwara K, Fujii M, Suzuki M, Kanda T
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Journal Title
J Cell Physiol
Volume: 225
Pages: 519-28
Peer Reviewed
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[Presentation] Local Brain Hypothermia Suppresses Perifocal Epileptiform Discharges Induced By Focal Cerebral Ischemia In Rats2012
Author(s)
Y. He, M. Fujii, T. Inoue, S. Nomura, Y. Maruta, Y. Owada, H. Kida, T. Yamakawa, T. Tokiwa, T. Yamakawa, M.Suzuki
Organizer
66thAnnual Meeting and 4th Biennial North American Epilepsy Congresss
Place of Presentation
San Diego USA
Year and Date
20121130-1204
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[Presentation] Inhibitory effects of focal brain cooling for motor cortical seizures in cats and nonhuman primates2011
Author(s)
Inoue T, He Y, Fujii M, Fujioka H, Tokiwa T, Kida H, Imoto H, Maruta Y, Nomura S, Yamakawa T, Suzuki M
Organizer
29thInternational Epilepsy Congress
Place of Presentation
Rome Italy
Year and Date
20110828-0901
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[Presentation] Alterative treatment of intractable epilepsy with focal brain cooling2011
Author(s)
Fujii M, Inoue T, Imoto H, Tanaka N, Oku T, Maruta Y, Koizumi H, Nomura S, Owada Y, Saito T, Yamakawa T, Tokiwa T, Yamakawa T, Suzuki M
Organizer
29th International Epilepsy Congress
Place of Presentation
Rome Italy
Year and Date
20110828-0901
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