2012 Fiscal Year Final Research Report
Development of a novel therapy for malignant glioma based on theSNIP-microarray analysis and Glioma Cancer Stem cell theory
| Project/Area Number |
22591616
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
NAKAMURA Hideo 熊本大学, 医学部附属病院, 講師 (30359963)
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| Co-Investigator(Kenkyū-buntansha) |
MAKINO Keishi 熊本大学, 医学部附属病院, 講師 (90381011)
HIDE Takuichiro 熊本大学, 医学部附属病院, 助教 (40421820)
KURATSU Jun-ichi 熊本大学, 大学院・生命科学研究部, 教授 (20145296)
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| Co-Investigator(Renkei-kenkyūsha) |
OGAWA Seishi 東京大学, 医学部付属病院, 准教授 (60292900)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 脳腫瘍学 |
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| Research Abstract |
We focused on the biological property of glioma cancer stem cellto investigate the mechanism of drug resistance in malignant glioma. We could maintainthe property of stem cell by culturing under the special condition and did an experimentof the biology of drug resistance. We investigated the genomic profiles of glioma cellsusing SNIP-microarray and found that genetic alterations such as p53 reduced thesensitivity of drugs. While, we also found that differentiation of the glioma cellscontributed to the sensitivity of drugs
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