2012 Fiscal Year Final Research Report
Towards molecular-guided personalized therapy of gliomas -clarifyingthe indication of neoadjuvant approach for gliomas-
| Project/Area Number |
22591619
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SASAKI Hikaru 慶應義塾大学, 医学部, 講師 (70245512)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 脳腫瘍学 |
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| Research Abstract |
We have conducted molecular/genetic analysis on more than 400gliomas to establish molecular classification of gliomas. As a result, gliomas of grade2-3 were shown to be classified into subgroups based on genetic profile that correlatewell with prognosis.
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[Journal Article] Kohmura E Immunohistochemicaland molecular genetics study of agranular cell astrocytoma: A casereport of malignant transformation toa glioblastoma2012
Author(s)
Ishii T, Mizukawa K, Sasayama T,Sasaki H, Hayashi S, Nakamizo S,Tanaka H, Tanaka K, Hara S, Hirai C,Itoh T
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Journal Title
Peer Reviewed
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[Journal Article] WholeGenome Analysis From MicrodissectedTissue Revealed Adult SupratentorialGrade II-III Gliomas Are Divided IntoClinically Relevant Subgroups byGenetic Profile2011
Author(s)
Hirose Y, Sasaki H, Miwa T, Ohba S,Ikeda E, Abe M, Ikeda S, Kobayashi M,Kawase T, Hasegawa M, Yoshida K
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Journal Title
Neurosurgery
Volume: 69(2)
Pages: 376-390
Peer Reviewed
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[Journal Article] Functional analysis of HOXD9 in humangliomas and glioma cancer stem cells2011
Author(s)
Tabuse M, Ohta S, Ohashi Y, Fukaya R,Misawa A, Yoshida K, Kawase T, Saya H,Thirant C, Chneiweiss H, Matsuzaki Y,Okano H, Kawakami Y, Toda M.
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Journal Title
Mol Cancer
Volume: 10(60)
Pages: 1-14
Peer Reviewed
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