2012 Fiscal Year Final Research Report
Contribution of The Pro-inflammatory Cytokines and Aquaporin 1 & 4 in the Progression
| Project/Area Number |
22591622
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | ラトケ嚢胞 / 炎症性サイトカイン / アクアポリン / ホルモン受容体 |
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| Research Abstract |
Expression of water-channel aquoporin 1 and 4 in Rathke epithelium might stimulate to progression of cyst. Over-expression of androgen receptor in Rathke epithelium might induce proliferation with Rathke epithelium itself and inflammation in adenohypophysis. So aquaporin and androgen receptor might be novel target molecules totreat with symptomatic Rathke cleft cyst.
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