Fundamental study of intractable pain using molecular imaging

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591623
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Meiji University of Integrative Medicine
• Principal Investigator: TANAKA Chuzo 明治国際医療大学, 医学教育研究センター, 教授 (80163541)
• Co-Investigator(Kenkyū-buntansha): HIGUCHI Toshihiro 明治国際医療大学, 医学教育研究センター, 教授 (80218700) ; UMEDA Masahiro 明治国際医療大学, 医学教育研究センター, 教授 (60223608) ; WATANABE Yasuharu 明治国際医療大学, 医学教育研究センター, 講師 (90454537) ; KAWAI Yuko 明治国際医療大学, 医学教育研究センター, 助教 (90555616)
• Project Period (FY): 2010 – 2012
• Keywords: 機能脳神経外科学

Research Abstract

It is difficult to assay a pain. MRI is used well to visualize activation of the central nerve. We have investigated areas relevant brain activation by using fMRI and visualized the brain activation patterns associated with pain stimuli. This is a first basic study of manual therapy using fMRI.

Research Products

• [Journal Article] Preparation of polymer-based multimodal imaging agent to visualize the process of bone regeneration. (2012)
  • Author(s): Liu J,Jo J,Kawai Y,Aoki I,Tanaka C, Yamamoto M , Tabata Y
  • Journal Title: J Control Release Volume: 157(3) Pages: 398-405
  • DOI: DOI:10.1016/j.jconrel.2011.09.090.
  • Peer Reviewed
• [Journal Article] Diffusion-weighted Spectroscopic Imagingによる脳虚血モデルラットの解析 (2012)
  • Author(s): 尾藤良孝,河合裕子,平田宏司,恵飛須俊彦,大竹陽介,平田智嗣,白猪亨,五月女悦久,越智久晃,梅田雅宏,樋口敏宏,田中忠蔵
  • Journal Title: 磁気共鳴学会雑誌 Volume: 32(1) Pages: 17-20
  • Peer Reviewed
• [Journal Article] 拡散テンソル画像(DTI)がもたらす情報-水分子の動きによる筋の微細構造評価を中心に (2012)
  • Author(s): 梅田雅宏,渡邉康晴,河合裕子,樋口敏宏,田中忠蔵
  • Journal Title: インナービジョン Volume: 27・3 Pages: 18-20
• [Journal Article] 拡散強調画像がもたらす情報-運動による水分子の動き評価を中心に (2012)
  • Author(s): 渡邉康晴,梅田雅宏,河合裕子,樋口敏宏,田中忠蔵
  • Journal Title: インナービジョン Volume: 27・3 Pages: 15-17
• [Journal Article] Inconsistency and Uncertainty of the Human Visual Area Loci followingSurface-based Registration.Probability and Entropy Maps (2012)
  • Author(s): Yamamoto H, Fukunaga M, Takahashi S, Mano H, Tanaka C, Umeda M, and Ejima Y
  • Journal Title: Hum Brain Mapp Volume: 33(1) Pages: 121-9
  • DOI: DOI:10.1002/hbm.21200
  • Peer Reviewed
• [Journal Article] In Vivo Assessment of Peripheral Nerve Regeneration by Diffusion Tensor Imaging (2011)
  • Author(s): Morisaki S, Kawai Y, Umeda M, Nishi M, Oda R, Fujiwara H, Yamada K, Higuchi T, Tanaka C, Kawata M, Kubo T
  • Journal Title: J of Magn Res Imag Volume: 33(3) Pages: 535-42
  • DOI: DOI:10.1002/jmri.22442.
  • Peer Reviewed
• [Journal Article] ヒト視運動野の単眼性奥行き視への関与. (2011)
  • Author(s): 山本哲也,山本洋紀,眞野博彰,梅田雅宏,田中忠蔵,齋木潤
  • Journal Title: 信学技報 Volume: 111,96 Pages: 79-84
  • URL: http://ci.nii.ac.jp/els/110008746494
• [Journal Article]
  • URL: http://www.kopas.co.jp/fmdb/JJMRM/32/
• [Journal Article]
  • URL: http://www.innervision.co.jp/01inner/2012/pdf/iv201203_018.pdf
• [Journal Article]
  • URL: http://www.innervision.co.jp/01inner/2012/pdf/iv201203_015.pdf
• [Presentation] Lowbを用いた拡散強調画像による心筋の収縮および拡張評価 (2012)
  • Author(s): 梅田雅宏,樋口敏宏,渡邉康晴,河合裕子,村瀬智一,関本達之,大門律雄,村松佑哉.
  • Organizer: 第40回日本磁気共鳴医学会大会
  • Year and Date: 2012-09-08
• [Presentation] 健常ラット脳のDiffusion Tensor Spectroscopic Imaging(DTSI) (2012)
  • Author(s): 尾藤良孝,河合裕子,平田宏司,恵飛須俊彦,大竹陽介,平田智嗣,白猪亨,五月女悦久,越智久晃,梅田雅宏,樋口敏宏,田中忠蔵
  • Organizer: 第40回日本磁気共鳴医学会大会
  • Year and Date: 2012-09-08
• [Presentation] DWIを用いた筋組織の圧変形とその回復過程の画像化 (2012)
  • Author(s): 渡邉康晴,木村啓作,梅田雅宏,河合裕子,樋口敏宏,田中忠蔵
  • Organizer: 第40回日本磁気共鳴医学会大会
  • Year and Date: 2012-09-07
• [Presentation] fMRI測定に用いる熱刺激システムの試作と性能検証 (2012)
  • Author(s): 村瀬智一,梅田雅宏,河合裕子,渡邉康晴,樋口敏宏,田中忠蔵
  • Organizer: 第40回日本磁気共鳴医学会大会
  • Year and Date: 2012-09-06
• [Presentation] Detection of Spontaneous Pain due to Chronic Pain in the Rat (2012)
  • Author(s): Yuko Kawai , Masahiro Umeda , Yasuharu Watanabe , Toshihiro Higuchi , Chuzo Tanaka
  • Organizer: International Society for Magnetic Resonance in Medicine 20th Annual Meeting & Exhibition,944
  • Year and Date: 2012-05-10
• [Presentation] Investigating the duration of brain response to acupuncture stimulation by using independent component analysis. (2012)
  • Author(s): Tomokazu Murase,Masahiro Umeda,Yuko Kawai , Yasuharu Watanabe , Toshihiro Higuchi,Chuzo Tanaka
  • Organizer: International Society for Magnetic Resonance in Medicine 20th Annual Meeting & Exhibition,759
  • Year and Date: 2012-05-10
• [Presentation] The investigation of apparent diffusion coefficient in renal cortex and medulla during the cardiac cycle. (2012)
  • Author(s): Masahiro Umeda,Toshihiro Higuchi,Yuki Mori , Yoshichika Yoshioka , Yasuharu Watanabe,Yuko Kawai,Tomokazu Murase, Chuzo Tanaka
  • Organizer: International Society for Magnetic Resonance in Medicine 20th Annual Meeting & Exhibition,1322
  • Year and Date: 2012-05-09
• [Presentation] Diffusion-weighted Spectroscopic Imaging of Multiple Metabolites in Rat Brains after Middle Cerebral Artery Occlusion. (2012)
  • Author(s): Yoshitaka Bito,Yuko Kawai,Koji Hirata, Toshihiko Ebisu,Yosuke Otake,Satoshi Hirata,Toru Shirai,Yoshihisa Soutome, Hisaaki Ochi,Masahiro Umeda,Toshihiro Higuchi , Chuzo Tanaka
  • Organizer: International Society for Magnetic Resonance in Medicine 20th Annual Meeting & Exhibition,463
  • Year and Date: 2012-05-08
• [Presentation] 触刺激に伴う心地良さに関するfMRI (2011)
  • Author(s): 村瀬智一,梅田雅宏,河合裕子,渡邉康晴,樋口敏宏,田中忠蔵
  • Organizer: 第39回日本磁気共鳴医学会大会
  • Place of Presentation: 小倉
  • Year and Date: 2011-09-29
• [Presentation] 非磁性超音波モータを用いたfMRI用印刷物呈示装置の開発 (2011)
  • Author(s): 川島康裕,山城博幸,市村好克,村瀬智一,梅田雅宏,樋口敏宏,山本洋紀
  • Organizer: 第13回日本ヒト脳機能マッピング学会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-01
• [Presentation] 印刷物知覚時のヒト視覚野におけるfMRI応答:照明レベル依存性 (2011)
  • Author(s): 川島康裕,山城博幸,山本洋紀,市村好克,村瀬智一,梅田雅宏,樋口敏宏
  • Organizer: 日本視覚学会2011年夏季大会
  • Place of Presentation: 福岡
  • Year and Date: 2011-08-04
• [Presentation] 非磁性超音波モータを用いた実物体刺激呈示装置のfMRI適合性評価 (2011)
  • Author(s): 山城博幸,川島康裕,村瀬智一,山本洋紀,市村好克,梅田雅宏,樋口敏宏
  • Organizer: 日本視覚学会2011年夏季大会
  • Place of Presentation: 福岡
  • Year and Date: 2011-08-04
• [Presentation] Retinotopic activities in extrastriate visual areas predict individual variations in binocular rivalry dynamics. (2011)
  • Author(s): Yamashiro H, Yamamoto H, Saiki J, Mano H, Umeda M, Tanaka C
  • Organizer: 15th annual meeting of the Association for the Scientific Study of Consciousness
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2011-06-10
• [Presentation] Diffusion Tensor Spectroscopic Imaging of Rat Brains . (2011)
  • Author(s): Y. Bito, Y. Kawai, K. Hirata, T. Ebisu, T. Shirai, S. Hirata1, Y. Soutome, H. Ochi, M. Umeda, T. Higuchi, and C. Tanaka
  • Organizer: International Society for Magnetic Resonance in Medicine 19th Annual Meeting & Exhibition
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2011-05-11
• [Presentation] In vivo Detection of Glial Activity after Transient Forebrain Ischemia using Manganese-enhanced MRI. (2011)
  • Author(s): Y. Kawai, Y. Yasuda, N. Tateishi, M. Umeda, Y. Watanabe, T. Higuchi, S. Furuya, S. Naruse, S. Fujita, and C. Tanaka
  • Organizer: International Society for Magnetic Resonance in Medicine 19th Annual Meeting & Exhibition
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2011-05-10
• [Presentation] Diffusion-weighted Spectroscopic Imaging of Rat Brains After Middle Cerebral Artery Occlusion. (2011)
  • Author(s): Y. Bito, Y. Kawai, K. Hirata, T. Ebisu, T. Shirai, S. Hirata1, Y. Soutome, H. Ochi, M. Umeda, T. Higuchi, and C. Tanaka
  • Organizer: International Society for Magnetic Resonance in Medicine 19th Annual Meeting & Exhibition
  • Place of Presentation: Montreal,Canada
  • Year and Date: 2011-05-09
• [Presentation] 非磁性超音波モータを用いたfMRI用印刷物呈示装置の開発 (2011)
  • Author(s): 川島康裕,山城博幸,市村好克,村瀬智一,梅田雅宏,樋口敏宏,山本洋紀
  • Organizer: 第13回日本ヒト脳機能マッピング学会
  • Place of Presentation: 栃木県
  • Year and Date: 2011-03-17
• [Presentation] 独立成分分析法を用いた鍼・偽鍼刺激に伴うBOLD信号変化の検討 (2011)
  • Author(s): 村瀬智一,梅田雅宏,河合裕子,渡辺康晴,樋口敏宏,田中忠蔵
  • Organizer: 第23回臨床MR脳機能研究会
  • Place of Presentation: 東京都
  • Year and Date: 2011-02-19
• [Presentation] 単眼性奥行き手掛かり統合におけるヒトMT/MST野の相違 (2011)
  • Author(s): 山本哲也,山本洋紀,眞野博彰,梅田雅宏,田中忠蔵,齋木潤
  • Organizer: 日本視覚学会2010年冬季大会
  • Place of Presentation: 東京都
  • Year and Date: 2011-01-19
• [Book] 磁気共鳴スペクトルの医学応用 -MRS の基 礎から応用まで (2012)
  • Author(s): 成瀬昭二
  • Total Pages: 96-103