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2012 Fiscal Year Final Research Report

Analyzing corticobasal network with deep brain stimulation and diffsion tensor imaging

Research Project

  • PDF
Project/Area Number 22591625
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionTazuke Kofukai Medical Research Institute

Principal Investigator

TODA Hiroki  公益財団法人田附興風会, 医学研究所 第5研究部, 研究員 (80414118)

Co-Investigator(Renkei-kenkyūsha) SAWAMOTO Nobukatsu  京都大学, 医学研究科, 助教 (90397547)
Project Period (FY) 2010 – 2012
Keywords機能脳神経外科学
Research Abstract

We have established a novel functional analyzing method by integrating anatomical and electrophysiological information from diffusion tensor imaging, fiber tractography, and deep brain stimulation in patients with advanced Parkinson’s disease. We clearly demonstrated the fiber tracts for pyramidal, extrapyramidal, spinothalamic, and thalamocortical netoworks in patients with deep brain stimulation. By mapping the electrical stimulation effects on the fiber tractgraphy and diffusion tensor imaging data, we generated functional neuroanatomical atlases were in each case. Also non-motor effects of deep brain stimulation were analyzed on the map of tractography, neuronal networks involved in sleep and psychiatric symptoms in advanced Parkinson’s disease.

  • Research Products

    (11 results)

All 2012 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (9 results)

  • [Journal Article] パーキンソン病に対する脳深部刺激療法の目標点決定法2011

    • Author(s)
      戸田弘紀
    • Journal Title

      脳神経外科

      Volume: 39(1) Pages: 25-35

    • Peer Reviewed
  • [Journal Article] Subthalamic nucleus deep brain stimulation restores normal rapid eye movement sleep in Parkinson's disease2011

    • Author(s)
      Nishida N, 他 Toda H. (corresponding author)
    • Journal Title

      Mov Disord

      Volume: 26(13) Pages: 2418-22

    • Peer Reviewed
  • [Presentation] Deep Brain Stimulation Therapy in Parkinson's Disease2012

    • Author(s)
      戸田弘紀
    • Organizer
      5th International Congress of Emirates Neuroscience Society(招待)
    • Place of Presentation
      ドバイ(UAE)
    • Year and Date
      2012-11-06
  • [Presentation] Approaching Surgical Target for Movement Disorders2012

    • Author(s)
      戸田弘紀
    • Organizer
      World Federation of Neurological Surgeon Educational Course(招待)
    • Place of Presentation
      ドバイ(UAE)
    • Year and Date
      2012-11-03
  • [Presentation] Validating diffusion tensor imaging of the thalamus with intraoperative mircroelectrode recording2012

    • Author(s)
      戸田弘紀
    • Organizer
      XXth European Society of Stereotactic and Functional Neurosurgery conference
    • Place of Presentation
      リスボン(ポルトガル)
    • Year and Date
      2012-09-28
  • [Presentation] 脳深部刺激療法で記録される大脳基底核・視床の神経活動2012

    • Author(s)
      戸田弘紀
    • Organizer
      神経オシレーションカンファレンス(招待)
    • Place of Presentation
      岡崎
    • Year and Date
      2012-07-13
  • [Presentation] Validating diffusion tensor imaging of the thalamus with intraoperative mircroelectrode recording2012

    • Author(s)
      戸田弘紀
    • Organizer
      2012 American Society of Stereotactic and Functional Neurosurgery meeting
    • Place of Presentation
      サンフランシスコ(アメリカ)
    • Year and Date
      2012-06-04
  • [Presentation] 拡散テンソル画像・神経線維束画像の視床脳深部刺激療法への応用2012

    • Author(s)
      戸田弘紀
    • Organizer
      第51回日本定位機能神経外科学会
    • Place of Presentation
      東京
    • Year and Date
      2012-01-21
  • [Presentation] Neuroimaging and Functional Neurosurgery for Movement Disorders2011

    • Author(s)
      戸田弘紀
    • Organizer
      World Federation of Neurological Surgeon教育講演(招待)
    • Place of Presentation
      ハノイ(ベトナム)
    • Year and Date
      2011-12-10
  • [Presentation] Neuroimaging and Functional Neurosurgery for Movement Disorders2011

    • Author(s)
      戸田弘紀
    • Organizer
      国際定位機能神経外科学会 Interim Meeting (招待)
    • Place of Presentation
      ケープタウン(南アフリカ)
    • Year and Date
      2011-11-22
  • [Presentation] Reaching the target in DBS2010

    • Author(s)
      戸田弘紀
    • Organizer
      14^<th> International Congress of Parkinson's Disease and Movement Disorders (招待)
    • Place of Presentation
      ブエノスアイレス(アルゼンチン)
    • Year and Date
      2010-06-14

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Published: 2014-08-29  

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