2012 Fiscal Year Final Research Report
Regeneration of rotator cuff using bioabsorbable scaffold without cultured cells
Project/Area Number |
22591655
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Kobe University |
Principal Investigator |
KOKUBU Takeshi 神戸大学, 大学院・医学研究科, 助教 (40403266)
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Co-Investigator(Kenkyū-buntansha) |
NAGURA Issei 神戸大学, 医学研究科, 医学研究員 (00437485)
KUROSAKA Masahiro 神戸大学, 医学研究科, 教授 (70170115)
MIFUNE Yutaka 神戸大学, 医学部附属病院, 助教 (80608464)
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Project Period (FY) |
2010 – 2012
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Keywords | 肩腱板広範囲断裂 / 腱板再生 / スキャフォールド / PLG / electrospinning 法 |
Research Abstract |
The purpose of this study was to evaluate an application of poly (D-L-lactide-co-glycolide) (PLG) scaffold in a rabbit rotator cuff defect model. Histologically, spindle shaped cells were observed inside of the scaffold at 4 weeks postoperatively. At 8 weeks, the PLG scaffold had dissolved andbone formation was observed at the scaffold-bone interface. At 16 weeks, the scaffold-bone interface matured and expression of type II collagen was observed. Biomechanically, statistical difference of ultimate failure load was not seen between scaffold group and normal tendon after 8 weeks postoperatively. This PLG scaffold could be applied to bridge rotator cuff defect.
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[Journal Article] Regeneration of Rotator Cuff Tear Using ElectrospunPoly(d,l-Lactide-Co-Glycolide) Scaffolds in a Rabbit Model2012
Author(s)
Inui A, Kokubu T, Mifune Y, Sakata R, Nishimoto H, Nishida K, Akisue T, Kuroda R, Satake M, Kaneko H, Fujioka H.
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Journal Title
Arthroscopy
Volume: 28(12)
Pages: 1790-1799
Peer Reviewed
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