2012 Fiscal Year Final Research Report
New Method using Boron Neutron Capture Therapy for Clear Cell Sarcoma
| Project/Area Number |
22591657
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
AKISUE Toshihiro 神戸大学, 医学研究科, 講師 (90379363)
ICHIKAWA Hideki 神戸学院大学, 薬学部, 教授 (00248105)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 明細胞肉腫 / ホウ素中性子捕捉療法 / BNCT |
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| Research Abstract |
Clear cell sarcoma (CCS) of tendons and aponeuroses is a rare malignant tumor of poor prognosis,with a predilection for youngadults.Although the standard treatment is still wide surgical resection, neither chemotherapy norradiotherapy is effective. Therefore, clearly new therapeutic strategies are required. Recently, boron neutron capture therapy (BNCT) with the use of p-boronophenylalanine (BPA) for malignant melanoma has provided good results. BecauseBPA is requisite for the production of melanin, boron is finally accumulated in tumor cells. CCS also produces melanin, and with the use of a cultured human CCS cell line andthrough human CCS-bearing animal studies, we have shown that the high accumulation of 10B is potentially favorable in BNCT. Therefore, we evaluated the short-term efficacy of BNCT for CCS with the use of human CCS cell line-bearing nude mice and have here, for thefirst time, demonstrated that BNCT is a potentially new option for the treatment of human CCS.
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[Journal Article] Boron neutron capture therapy (BNCT) selectively destroys human clear cell sarcoma in mouse model2013
Author(s)
Fujimoto T, Andoh T, Sudo T, Fujita I, Moritake H, Sugimoto T, Sakuma T, Akisue T, Kawabata S, Kirihata M, Suzuki M, Sakurai Y, Ono K, Fukumori Y, Kurosaka M, Ichikawa H
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Journal Title
Appl Radiat Isot
Volume: 73
Pages: 96-100
URL
Peer Reviewed
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[Journal Article] Evaluation of BPA uptake in clear cell sarcoma (CCS) in vitro and development of an in vivo model of CCS for BNCT studies2011
Author(s)
Fujimoto T, Andoh T, Sudo T, Fujita I, Imabori M, Moritake H, Sugimoto T, Sakuma Y, Takeuchi T, Sonobe H, Epstein AL, Akisue T, Kirihata M, Kurosaka M, Fukumori Y, Ichikawa H
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Journal Title
Appl Radiat Isot.
Volume: 69
Pages: 1713-6
URL
Peer Reviewed
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[Journal Article] Boron neutron capture therapy for clear cell sarcoma (CCS): biodistribution study of p-borono-L-phenylalanine in CCS-bearing animal models.2011
Author(s)
Andoh T, Fujimoto T, Sudo T, Fujita I, Imabori M, Moritake H, Sugimoto T, Sakuma Y, Takeuchi T, Kawabata S, Kirihata M, Akisue T, Yayama K, Kurosaka M, Miyatake S, Fukumori Y, Ichikawa H
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Journal Title
Appl Radiat Isot
Volume: 69
Pages: 1721-4
URL
Peer Reviewed
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