2012 Fiscal Year Final Research Report
Anti-tumor effect of doxorubicin with bubble liposome and ultrasound
Project/Area Number |
22591662
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Orthopaedic surgery
|
Research Institution | Kagoshima University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
ZEMMYO Michihisa 鹿児島大学, 医学部, 助教 (10289465)
KOMIYA Setsuro 鹿児島大学, 医学部, 教授 (30178371)
|
Research Collaborator |
UENO Yoshinori 鹿児島大学, 医学部, 大学院生
|
Project Period (FY) |
2010 – 2012
|
Keywords | 骨軟部肉腫 / 化学療法 / 抗癌剤 / 有害事象 |
Research Abstract |
We constructed a drug delivery system by concomitant use of ultorasound with doxorubicin, a key drug in the chemotherapy of osteosarcoma, and demonstrated both in vitroand in vivothat this drug delivery system markedly inhibited the proliferation of osteosarcoma cells and pulmonary metastasis.
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