2012 Fiscal Year Final Research Report
Functional analysis of Smoothened in osteosarcoma via signal cross talk
| Project/Area Number |
22591663
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kagoshima University |
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Principal Investigator |
YAMAMOTO Takuya 鹿児島大学, 医学部・歯学部附属病院, 講師 (40381157)
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| Co-Investigator(Kenkyū-buntansha) |
SETOGUCHI Takao 鹿児島大学, 大学院・医歯学総合研究科, 特任准教授 (40423727)
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| Co-Investigator(Renkei-kenkyūsha) |
KOMIYA Setsuro 鹿児島大学, 大学院・医歯学総合研究科, 教授 (30178371)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 骨肉腫 / Hedgehog Smoothened / 転移 |
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| Research Abstract |
We have examined the function of Hedgehog pathway in osteosarcoma cell proliferation, metastasis, and cancer stem cells. We found activation of Hedgehog pathway in human osteosarcoma. Inhibition of Smoothened (SMO) prevented osteosarcoma cell proliferation by cell cycle regulation in vitro and in vivo. In addition, pharmacological inhibition of SMO or GLI prevents human rhabdomyosarcoma cell proliferation. Furthermore, inhibition of GLI2 prevents osteosarcoma cell proliferation, invasion, and lung metastasis. We have already found that other signal related molecule regulate the osteosarcoma cell metastasis by Hedgehog signal activation.
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