2012 Fiscal Year Final Research Report
Analysis of response mechanism of osteoblast by physical stimulation -mechanical stress and electrical stimulation
| Project/Area Number |
22591667
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KIM Wook-cheol 京都府立医科大学, 大学院・医学研究科運動器機能再生外科学(整形外科学教室), 准教授 (50244603)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 細胞・組織 / シグナル伝達 / 生体分子 / 再生医学 / 医療・福祉 |
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| Research Abstract |
We conducted an alternating current electrical stimulation to theosteoblastic cell line MC3T3-E1, and examined the phosphorylation of MAPK(mitogen-activated protein kinase) as an indicator . By the AC electrical stimulation for 20 min, phosphorylation of ERK and p38 (MAPK) was increased significantly than thenon-stimulated group. Part of the response mechanism for electrical stimulation of osteoblasts been elucidated, the establishment of stimulus conditions and methods of useful mechanical stress can be expected.
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Research Products
(9 results)
