2012 Fiscal Year Final Research Report
Development of vascularized artificial bone with mesenchymal stem cells
| Project/Area Number |
22591670
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Nara Medical University |
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Principal Investigator |
MURATA Keiichi 奈良県立医科大学, 整形外科学, 講師 (10382318)
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| Co-Investigator(Renkei-kenkyūsha) |
AKAHANE Manabu 奈良県立医科大学, 健康政策医学, 准教授 (40326327)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 四肢機能再建学 |
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| Research Abstract |
Based on tissue engineering technology, a vascularized artificial bone grafting model using a beta-tricalcium phosphate (βTCP) which can replace to autogenous bone was designed. Using animals (rats), vascularization and new bone formation into the artificial bone by implantation of vascular bundle and mesenchymal stem cells (MSCs) were evaluated. By implantation of the femoral artery and vein to center of the artificial bone and the osteogenic matrix cell-sheet (OMCS) at boundary surface between the implanted vessels and the artificial bone, vigor new bone formation and angiogenesis in the artificial bone were observed. This technique will be applied clinically to treat intractable nonunion of fractures.
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