2012 Fiscal Year Final Research Report
Analysis of osteoarthritis: skeletal dysplasia due to type IIcollagen deficiency as a model
| Project/Area Number |
22591683
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | University of Toyama |
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Principal Investigator |
MATSUI Yoshito 富山大学, 大学院・医学薬学研究部(医学), 助教 (80335348)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 関節病学 / コラーゲン / 骨系統疾患 |
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| Research Abstract |
Czech dysplasia, showing early-onset osteoarthritis, is a skeletal dysplasia caused by a specific Arg275Cys mutation of the type II collagen. In order to investigate the pathomechanisms of osteoarthritis, focusing on the metabolism of type II collagen molecule and supramolecular structure of the collagen matrix, the principal investigator generated transgenic mice bearing type II collagen with Arg275Cys mutation overexpressed by the mouse type II collagen gene promoter and enhancer. Two independent inbred lines of transgenic mice were established.
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