2012 Fiscal Year Final Research Report
Development of cartilage directed multifunctional nano-probes for diagnosis and treatment of osteoarthritis.
| Project/Area Number |
22591686
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Okayama University |
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Principal Investigator |
OOHASHI Toshitaka 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (50194262)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIDA Keiichiro 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (80284058)
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| Co-Investigator(Renkei-kenkyūsha) |
KOMATSU Naoki 滋賀医科大学, 医学部, 准教授 (30253008)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 関節軟骨 / プロテオグリカン / MRI / マトリックスメタロプロテアーゼ / 分子標的化 |
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| Research Abstract |
Current research aimed to develop a new multifunctional nano-probes for diagnosis and treatment of osteoarthritis, which will increase according to the acceleration of demographic aging. We could demonstrate the effect of cartilage-specific contrast agent, octaarginine peptide conjugated with DOTA-Gd, in ex vivo and in vivo experiments of rabbit knee joints. While R8-N-TIMP3, designed as a cartilage protective agent, did not show sufficient protective effect in a mouse model of rheumatoid arthritis although it showed in ex vivo tissue culture experiments. Further study is necessary after a prolonged expression of R8-NTIMP-3 in the arthritic knee joints.
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[Journal Article] RXR Partial Agonist CBt-PMN Exerts Therapeutic Effects on Type 2 Diabetes without the Side Effects of RXR Full Agonists2012
Author(s)
H Kakuta, N Yakushiji, R Shinozaki, F Ohsawa, S Yamada, Y Ohta, K Kawata, M Nakayama, M Hagaya, C Fujiwara, M Makishima, S Uno, A Tai, A Maehara, M Nakayama, T Oohashi, H Yasui, and Y Yoshikawa
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Journal Title
ACS Med. Chem. Lett.
Volume: 3
Pages: 427-432
Peer Reviewed
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[Journal Article] Bral1: its role in diffusion barrier formation and conduction velocity in the CNS.2010
Author(s)
Bekku Y, Vargova L, Goto Y, Vorisek I, Dmytrenko L, Narasaki M, Ohtsuka A, Fassler R, Ninomiya Y, Sykova E, Oohashi T
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Journal Title
J Neurosci
Volume: 30(8)
Pages: 3113-23
Peer Reviewed
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