2012 Fiscal Year Final Research Report
Identification and cell line establishment of human osteoclast precursor cell
| Project/Area Number |
22591690
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HORIUCHI Keisuke 慶應義塾大学, 医学部, 講師 (30327564)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYAMOTO Takeshi 慶應義塾大学, 医学部, 特任准教授 (70383768)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 破骨細胞 / 不死化 / Abelson virus / レトロウイルス |
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| Research Abstract |
Acquisition of cDNA of Abelson virus was tried and it succeeded in identification of a full length clone. When gene sequences were analyzed using the Direct sequence method, it was checked that there is no problem in gene sequences. A restriction enzyme s
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[Journal Article] An essential role for STAT6-STAT1 protein signaling in promoting macrophage cell-cell fusion2012
Author(s)
Miyamoto H, Katsuyama E, Miyauchi Y, Hoshi H, Miyamoto K, Sato Y, Kobayashi T, Iwasaki R, Yoshida S, Mori T, Kanagawa H, Fujie A, Hao W, Morioka H, Matsumoto M, Toyama Y, Miyamoto T
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Journal Title
J Biol Chem
Volume: 287(39)
Pages: 32479-84
Peer Reviewed
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[Journal Article] Conditional inactivation of Blimp1 in adult mice promotes increased bone mass.2012
Author(s)
Miyauchi Y, Miyamoto H, Yoshida S, Mori T, Kanagawa H, Katsuyama E, Fujie A, Hao W, Hoshi H, Miyamoto K, Sato Y, Kobayashi T, Akiyama H, Morioka H, Matsumoto M, Toyama Y, Miyamoto T.
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Journal Title
J Biol Chem
Volume: 287(34)
Pages: 28508-17
Peer Reviewed
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[Journal Article] Enhanced susceptibility to lipopolysaccharide-induced arthritis and endotoxin shock in interleukin-32 alpha transgenic mice through induction of tumor necrosis factor alpha2012
Author(s)
Nakayama M, Niki Y, Kawasaki T, Takeda Y, Horiuchi K, Sasaki A, Okada Y, Umezawa K, Ikegami H, Toyama Y, Miyamoto T.
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Journal Title
Arthritis Res Ther
Volume: 14(3)
Pages: R120
Peer Reviewed
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[Journal Article] PDGFBB promotes PDGFRα-positive cell migration into artificial bone in vivo2012
Author(s)
Yoshida S, Iwasaki R, Kawana H, Miyauchi Y, Hoshi H, Miyamoto H, Mori T, Kanagawa H, Katsuyama E, Fujie A, Hao W, Kobayashi T, Sato Y, Miyamoto K, Morioka H, Matsumoto M, Chiba K, Toyama Y, Nakagawa T, Miyamoto T
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Journal Title
Biochem Biophys Res Commun.
Volume: 421(4)
Pages: 785-9
Peer Reviewed
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[Journal Article] Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis2012
Author(s)
Hoshi H, Hao W, Fujita Y, Funayama A, Miyauchi Y, Hashimoto K, Miyamoto K, Iwasaki R, Sato Y, Kobayashi T,Miyamoto H, Yoshida S, Mori T, Kanagawa H, Katsuyama E, Fujie A, Kitagawa K, Nakayama KI, Kawamoto T, Sano M, Fukuda K, Ohsawa I, Ohta S, Morioka H
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Journal Title
J Bone Miner Res.
Volume: 27(9)
Pages: 2015-23
Peer Reviewed
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[Journal Article] Osteoclast stimulatory transmembrane protein and dendritic cell-specific transmembrane protein cooperatively modulate cell-cell fusion to form osteoclasts and foreign body giant cells2012
Author(s)
Miyamoto H, Suzuki T, Miyauchi Y, Iwasaki R, Kobayashi T, Sato Y, Miyamoto K, Hoshi H, Hashimoto K, Yoshida S, Hao W, Mori T, Kanagawa H, Katsuyama E, Fujie A, Morioka H, Matsumoto M, Chiba K, Takeya M, Toyama Y, Miyamoto T
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Journal Title
J Bone Miner Res
Volume: 27(6)
Pages: 1289-97
Peer Reviewed
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