2012 Fiscal Year Final Research Report
Investigation of articular cartilage degeneration and osteophyte formation in osteoarthritis using smoothened cond I t iona l knockout mice
| Project/Area Number |
22591695
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAMURA Toshitaka 産業医科大学, 医学部, 教授 (50082235)
OTOMO Hajime 産業医科大学, 医学部, 助教 (40550372)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 骨・軟骨代謝学 / 変形性関節症 / 骨棘 / ヘッジホッグ / Cre-ER(T) |
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| Research Abstract |
Osteophyte formation is a common phenomenon in osteoarthritis. Endochondral ossification is considered an important pathophysiological process for osteophyte fornlation. We investigated whether the deletion of smoothened (Smo), a key component of the hedgehog pathway in the process of enchondral ossification, inhibits osteophyte formation in nlouse osteoarthritis. The attenuation of osteophyte was shown in the mice deleted Smo, indicating that hedgehog signaling has a critical role in the osteoarthritis.
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